572636

InSolution SU6656-Calbiochem

InSolution, ≥95%, inhibitor of Src-family protein tyrosine kinases

• 同義詞: InSolution SU6656
• 經驗公式（希爾表示法）: C₁₉H₂₁N₃O₃S
• 分子量：: 371.45
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: liquid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic); protect from light
• 運輸包裝: wet ice
• 儲存溫度: 2-8°C

描述

一般說明

A potent inhibitor of Src-family protein tyrosine kinases. Inhibits Src (IC₅₀ = 280 nM) as well as closely related kinases Fyn (IC₅₀ = 170 nM), Yes (IC₅₀ = 20 nM) and Lyn (IC₅₀ = 130 nM). The inhibition is competitive with respect to ATP. Has only a trivial effect on Lck (IC₅₀ = 6.88 µM). Does not affect the activity of PDGF-β receptor kinase (IC₅₀ >10 µM) and IGF-1 receptor kinase (IC₅₀ gt;20 µM).

生化／生理作用

Cell permeable: yes

Product competes with ATP.

Reversible: yes

Target IC₅₀: 280 nM inhibiting Src

包裝

Packaged under inert gas

警告

Toxicity: Irritant (B)

外觀

A 10 mM (500 µg/135 µl) solution of SU6656 (Cat. No. 572635) in DMSO.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: 188.6 °F - closed cup - (Dimethylsulfoxide)
• 閃點（°C）: 87 °C - closed cup - (Dimethylsulfoxide)