529576

PP2

≥95% (HPLC), liquid, Src protein tyrosine kinase inhibitor, Calbiochem^®

• 同義詞: InSolution PP2
• 經驗公式（希爾表示法）: C₁₅H₁₆ClN₅
• 分子量：: 301.77
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 產品名稱: PP2, InSolution, ≥95%, 10 mM, reversible ATP-competitive inhibitor of the Src family of protein tyrosine kinases
• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: liquid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: clear colorless
• 運輸包裝: wet ice
• 儲存溫度: −20°C

描述

一般說明

A potent and selective inhibitor of the src family of tyrosine kinases. Its action is similar to PP1. Selectively inhibits p56^lck (IC₅₀ = 4 nM), p59^fynT (IC₅₀ = 5 nM), and Hck (IC₅₀ = 5 nM) compared to other tyrosine kinases, such as EGF-R (IC₅₀ = 480 nM), JAK2 (IC₅₀ >50 µM) or ZAP-70 (IC₅₀ >100 µM). Also potently inhibits anti-CD3-stimulated tyrosine phosphorylation of human T cells (IC₅₀ = 600 nM).

生化／生理作用

Cell permeable: no

Primary Target
p56^lck

Product competes with ATP.

Reversible: yes

Target IC₅₀: 4 nM, 5 nM, 5 nM, 100 nM, against p56lck, p59fynT, Hck , and Src, respectively; 600 nM against anti-CD3-stimulated tyrosine phosphorylation of human T cells

包裝

Packaged under inert gas

警告

Toxicity: Irritant (B)

外觀

A 10 mM (1 mg/331 µl) solution of PP2 (Cat. No. 529573) in DMSO.

重構

Following initial thaw, aliquot, purge with inert gas, and freeze (-20°C).

其他說明

Hanke, J.H., et al. 1996. J. Biol. Chem.271, 695.



Selected Citations
Lee, J., et al. 2009. Cell Stem Cell5, 76.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: 188.6 °F - closed cup - (Dimethylsulfoxide)
• 閃點（°C）: 87 °C - closed cup - (Dimethylsulfoxide)