559418

SBHA

A cell-permeable bishydroxamic acid histone deacetylase (HDAC) inhibitor with anti-tumor properties.

• 同義詞: SBHA, Suberic Bishydroxamate, Suberoyl Bishydroxamic Acid, HDAC Inhibitor XII
• 經驗公式（希爾表示法）: C₈H₁₆N₂O₄
• CAS號碼: 38937-66-5
• 分子量：: 204.22
• MDL號碼: MFCD00192455
• 分類程式碼代碼: 51111800
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥95% (TLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 顏色: white to off-white
• 溶解度: DMSO: 10 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C8H16N2O4/c11-7(9-13)5-3-1-2-4-6-8(12)10-14/h13-14H,1-6H2,(H,9,11)(H,10,12)
• InChI 密鑰: IDQPVOFTURLJPT-UHFFFAOYSA-N

描述

一般說明

A cell-permeable bishydroxamic acid histone deacetylase (HDAC) inhibitor with anti-tumor properties. Causes an increase in acetylated histone H4 in MEL cells and inhibits the human HDAC1 and HDAC3 activities with a similar potency (ID₅₀ ~ 250-300 nM). Belongs to the hybrid polar class of compounds that acts both as inducers of differentiation of transformed cells and apoptosis. Suppresses the growth of proliferating keratinocytes and squamous cell carcinoma cells (IC₅₀ = 11.57 µM and 5.39 µM, respectively).

A cell-permeable bishydroxamic acid histone deacetylase (HDAC) inhibitor with anti-tumor properties. Reported to cause an increase in acetylated histone H4 in MEL cells. Also reported to inhibit human HDAC1 and HDAC3 activities with a similar potency (ID₅₀ ~ 250-300 nM). Belongs to the hybrid polar class of compounds that induce both differentiation of transformed cells and apoptosis. Shown to suppress the growth of proliferating keratinocytes and squamous cell carcinoma cells (IC₅₀ = 11.57 µM and 5.39 µM, respectively).

生化／生理作用

Cell permeable: yes

Primary Target
human HDAC1 and HDAC3 activities

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 11.57 µM and 5.39 µM in suppressing the growth of proliferating keratinocytes and squamous cell carcinoma cells, respectively

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.





From Catalog:

Desc. Field- added "cell-permeable"

其他說明

Brinkmann, H., et al. 2001. J. Biol. Chem.276, 22491.
Richon, V.M., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 3003.
Richon, V.M., et al. 1996. Proc. Natl. Acad. Sci. USA93, 5705.
Marks, P.A., 1994. Proc. Natl. Acad. Sci. USA91, 10251.

法律資訊

Not available for sale in the United States.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable