559397

SB 202190

InSolution, ≥98%, p38 MAP kinase inhibitor

• 同義詞: InSolution SB 202190, InSolution p38 MAP Kinase Inhibitor II
• 經驗公式（希爾表示法）: C₂₀H₁₄FN₃O
• CAS號碼: 152121-30-7
• 分子量：: 331.34
• MDL號碼: MFCD00941964
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: liquid
• 效力: 16 nM IC₅₀; 16 nM K_i
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• InChI: 1S/C20H14FN3O/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(25)8-4-15/h1-12,23-24H
• InChI 密鑰: NJNKPVPFGLGHPA-UHFFFAOYSA-N

描述

一般說明

A potent and cell-permeable inhibitor of p38 MAP kinase. Inhibits p38 phosphorylation of myelin basic protein (MBP) with no effect on the activity of the ERK or JNK MAP kinase subgroups. Also inhibits the kinase activity of p38β (IC₅₀ = 350 nM) and p38 phosphorylation of activating transcription factor 2 (ATF-2; IC₅₀ = 280 nM). Blocks LPS-induced TNF-α and interleukin biosynthesis. Reported to block LDL expression in Hep52 cells.

生化／生理作用

Cell permeable: yes

Primary Target
P38β

Product competes with ATP.

Reversible: yes

Target K_i: 350 nM against the kinase activity of p38β; 280 nM against p38 phosphorylation of activating transcription factor 2 (ATF-2)

包裝

Packaged under inert gas

Please refer to vial label for lot-specific concentration.

警告

Toxicity: Irritant (B)

外觀

A 1 mg/ml solution of SB 202190 (Cat. No. 559388) in anhydrous DMSO.

重構

Following initial thaw, aliquot and freeze (-20°C).

其他說明

Ajizian, S.J., et al. 1999. J. Infect. Dis.179, 939.
Singh, R.P., et al. 1999. J. Biol. Chem.274, 19593.
Wang, S.W., et al. 1999. Inflamm. Res.48, 533.
Gallagher, T.F., et al. 1997. Bioorg. Med. Chem.5, 49.
Jiang, Y., et al. 1996. J. Biol. Chem.271, 17920.
Kramer, R.M., et al. 1996. J. Biol. Chem.271, 27723.
Li, Z., et al. 1996. Biochem. Biophys. Res. Commun.228, 334.
Lee, L.C., et al. 1994. Nature372, 739.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: 188.6 °F - closed cup - (Dimethylsulfoxide)
• 閃點（°C）: 87 °C - closed cup - (Dimethylsulfoxide)