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重要文件

5.31170

Sigma-Aldrich

ALDH3A1 Inhibitor, CB29

同義詞:

ALDH3A1 Inhibitor, CB29, Aldehyde dehydrogenase ALDH3A1 inhibitor, CB29

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About This Item

經驗公式(希爾表示法):
C15H15N3O5S
分子量::
349.36
分類程式碼代碼:
12352200
NACRES:
NA.77

化驗

≥98% (HPLC)

品質等級

形狀

powder

效力

4.7 μM Ki

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

yellow

溶解度

DMSO: 50 mg/mL

儲存溫度

2-8°C

一般說明

A cell permeable diarylamine derivative that acts as a selective, reversible, substrate-binding site directed inhibitor of aldehyde dehydrogenase ALDH3A1 (Ki = 4.7 µM, IC50 = 16 µM). Does not inhibit the activity of ALDH1A1, ALDH1A2, ALDH1A3, ALDH1B1, and ALDH2 even at higher concentrations (250 µM). Shown to significantly reduce the activity of ALDH3A1 in A549 and SF767 cell lysates, but does not affect CCD-13Lu cells that lack ALDH3A1 activity. Although it does not affect tumor cell proliferation, it significantly improves the sensitivity of cancer cells to mafosfamide.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

生化/生理作用

Primary Target
ALDH3A1
Reversible: yes

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Parajuli, B. et al. 2014. Chembiochem.15, 701.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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