H2625

血红蛋白 来源于牛血液

suitable for protease substrate, substrate powder

• 同義詞: Hb, 牛血红蛋白, 高铁血红蛋白
• CAS號碼: 9008-02-0
• MDL號碼: MFCD00131282
• 分類程式碼代碼: 12352202
• eCl@ss: 42030116
• NACRES: NA.61

屬性

• 生物源: bovine blood
• 形狀: substrate powder
• 分子量: M_r ~64500
• 技術: activity assay: suitable
• 溶解度: H₂O: soluble 20 mg/mL
• 適合性: suitable for protease substrate
• UniProt登錄號: P01966; P02070; P02081; P06642; P06643
• 儲存溫度: 2-8°C
• 基因資訊: cow ... HBA1(281221) , HBB(280813) , HBE2(513240) , HBE4(513108) , HBG(511735) , alpha globin(512439)

描述

一般說明

Hemoglobin is the major component of red blood cells and is responsible for their red color. Its normal concentration in erythrocytes is 34%. Hemoglobin is a globular protein with α and β chains with every 141 and 146 amino acids respectively. It exists as a tetramer with each monomer having heterocyclic porphyrin ring with iron constituting the heme.

Hemoglobin is the major component of red blood cells, and is responsible for their red color. Its normal concentration in erythrocytes is 34%. Hemoglobin is the most important respiratory protein of vertebrates by virtue of its ability to transport oxygen from the lungs to body tissues, and to facilitate the return transport of carbon dioxide.

應用

Hemoglobin from bovine blood has been used as a substrate in cathepsin D activity assay. It has also been used to measure the activity of acid proteases (pepsin-like) in the stomach extract.

α-弹性蛋白的溶解度已被应用于弹性蛋白模拟生物材料的构建。

生化／生理作用

氧气转运蛋白。Fe²⁺/Fe³⁺平衡是血液氧合的一种生理指标；脱氧血红蛋白通过将亚硝酸还原为NO来补充反馈回路，而NO是一种可增强血液流向缺氧组织流量的血管扩张剂。

Bovine hemoglobin is used in the production of hemoglobin-vesicles (HbV). It has high thermal stability and high oxygen affinity when compared to human hemoglobin. Bovine hemoglobin interacts with synthetic and azo dyes. Polymerized forms of bovine hemoglobin are used to treat autoimmune hemolytic anemia.

注意

由于天然血红蛋白在空气中易于氧化，因此这些制剂主要为高铁血红蛋白。

準備報告

Prepared from washed, lysed and dialyzed erythrocytes.

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable
• 個人防護裝備: Eyeshields, Gloves, type N95 (US)