528245

PLD Inhibitor, FIPI

The PLD Inhibitor, FIPI controls the biological activity of PLD. This small molecule/inhibitor is primarily used for Membrane applications.

• 同義詞: PLD Inhibitor, FIPI, Compound 4k, PLD Inhibitor I
• 經驗公式（希爾表示法）: C₂₃H₂₄FN₅O₂
• CAS號碼: 939055-18-2
• 分子量：: 421.47
• MDL號碼: MFCD18382115
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥99% (HPLC)
• 形狀: powder
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: off-white
• 溶解度: DMSO: 100 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• SMILES 字串: O=C(C1=CC2=C(C=CC(F)=C2)N1)NCCN3CCC(N4C(NC5=C4C=CC=C5)=O)CC3

描述

一般說明

A cell-permeable, PLD1/2 inhibitor (IC₅₀ = 1 nM and 10 nM for PLD1 and PLD2, respectively, in a CHO cell based assay, and IC₅₀ = 20 nM for PLD2 in a biochemical assay), that displays no activity toward MitoPLD, and is selective for PLD1 and PLD2 over other PLD superfamily enzymes. It is also shown to block PLD2-dependent effects on cytoskeletal reorganization and cell trafficking in CHO cells, and diminish fMLP-directed neutrophil chemotaxis in HL60 cells at 750 nM. Unlike 1-butanol, this compound does not affect glucose-stimulated insulin secretion in Min6 pancreatic β-cells.

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

其他說明

Su, W., et al. 2009. Mol Pharmacol75, 437.
Monovich, L., et al. 2007. Bioorg Med Chem17, 2310.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable