527455

PKR Inhibitor, Negative Control

The PKR Inhibitor, Negative Control, also referenced under CAS 852547-30-9, controls the biological activity of PKR. This small molecule/inhibitor is primarily used for Phosphorylation & Dephosphorylation applications.

• 同義詞: PKR Inhibitor, Negative Control, RNA-Dependent Protein Kinase Inhibitor, Negative Control, 5-Chloro-3-(3,5-dichloro-4-hydroxybenzylidene)-1,3-dihydro-indol-2-one
• 經驗公式（希爾表示法）: C₁₅H₈Cl₃NO₂
• CAS號碼: 852547-30-9
• 分子量：: 340.59
• MDL號碼: MFCD09037552
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥95% (sum of two isomers, HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: yellow
• 溶解度: DMSO: 10 mg/mL; ethanol: 10 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• SMILES 字串: Clc1c(c(cc(c1)C=C2c3c(ccc(c3)Cl)NC2=O)Cl)O
• InChI: 1S/C15H8Cl3NO2/c16-8-1-2-13-9(6-8)10(15(21)19-13)3-7-4-11(17)14(20)12(18)5-7/h1-6,20H,(H,19,21)
• InChI 密鑰: ZJFMARHFPUZEKI-UHFFFAOYSA-N

描述

一般說明

An oxindole compound that serves as a negative control for PKR Inhibitor (Cat. No. 527450). Shown to be inactive in inhibiting RNA-induced PKR autophosphorylation (IC₅₀ >100 µM) or in rescuing PKR-dependent translation block.

An oxindole compound that serves as a negative control for PKR Inhibitor (Cat. No. 527450). Shown to be inactive in the inhibition of RNA-induced PKR autophosphorylation (IC₅₀ >100 µM). Exhibits no ability to rescue the translational block imposed by human PKR.

生化／生理作用

Cell permeable: no

Primary Target
A negative control for PKR Inhibitor

Product does not compete with ATP.

Reversible: no

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

其他說明

Jammi, N.V., et al. 2003. Biochem. Biophys. Res. Commun.308, 50.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1