525145

sPLA₂-IIA Inhibitor I

The sPLA₂-IIA Inhibitor I controls the biological activity of sPLA₂-IIA. This small molecule/inhibitor is primarily used for Cell Signaling applications.

• 同義詞: sPLA₂-IIA Inhibitor I, c(2NapA)LS(2NapA)R, TFA
• 經驗公式（希爾表示法）: C₄₁H₅₀N₈O₆ · xC₂HF₃O₂
• 分子量：: 750.89 (free base basis)
• 分類程式碼代碼: 41106300
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: lyophilized solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic)
• 顏色: white
• 溶解度: DMSO: 5 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C

描述

一般說明

A highly hydrophobic cyclic pentapeptide that selectively binds and acts as a potent inhibitor of human type IIA secreted phospholipase A₂ (sPLA₂-IIA) (IC₅₀ = 12.8 µM). Reported to effectively block sPLA₂-IIA-induced PGE₂ production at 100 nM in human rheumatoid synoviocytes and is non-toxic at doses up to 10 µM. Does not have any significant effect on the activities of porcine sPLA₂-IB, Naja naja sPLA₂-IB, or Crotalus durissus sPLA₂-IIA at 10 µM.

A highly hydrophobic cyclic pentapeptide that selectively binds and acts as a potent inhibitor of sPLA₂-IIA (human type IIA secreted phospholipase A₂; IC₅₀ = 12.8 μM). Shown to effectively block sPLA₂-IIA-induced PGE₂ production at 100 nM in human rheumatoid synoviocytes and is non-toxic at doses up to 10 μM. Does not have any significant effect on the activities of porcine sPLA₂-IB, Naja naja sPLA₂-IB, or Crotalus durissus sPLA₂-IIA even at 10 μM concentration.

生化／生理作用

Cell permeable: no

Primary Target
sPLA2-IIA (human type IIA secreted phospholipase A2

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 12.8 µM against sPLA2-IIA (human type IIA secreted phospholipase A2

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

序列

cyclic(2-NaphthylAla-Leu-Ser-2-NaphthylAla-Arg)•TFA

其他說明

Church, W.B., et al. 2001. J. Biol. Chem.276, 33156.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable