513030

PD 169316

A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC₅₀ = 89 nM).

• 同義詞: PD 169316, 4-(4-Fluorophenyl)-2-(4-nitrophenyl)-5-(4-pyridyl)-1H-imidazole
• 經驗公式（希爾表示法）: C₂₀H₁₃FN₄O₂
• CAS號碼: 152121-53-4
• 分子量：: 360.34
• MDL號碼: MFCD12405019
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: orange-yellow
• 溶解度: DMSO: 10 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C
• InChI: 1S/C20H13FN4O2/c21-16-5-1-13(2-6-16)18-19(14-9-11-22-12-10-14)24-20(23-18)15-3-7-17(8-4-15)25(26)27/h1-12H,(H,23,24)
• InChI 密鑰: BGIYKDUASORTBB-UHFFFAOYSA-N

描述

一般說明

A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC₅₀ = 89 nM). Inhibition of p38 MAP kinase by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines.

A potent, cell-permeable, reversible, competitive, and selective p38 MAP kinase inhibitor (IC₅₀= 89 nM). Inhibition of p38 MAP kinase by PD 169316 blocks apoptosis induced by trophic factor withdrawal in non-neuronal and neuronal cell lines.

生化／生理作用

Cell permeable: yes

Primary Target
p38 MAP kinase

Product competes with ATP.

Reversible: yes

Target IC₅₀: 89 nM against p38 MAP kinase

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 4 months at -20°C.

其他說明

Nath, R., et al. 2001. Cell Mol. Biol. Lett.6, 173.
Gallagher, T.F., et al. 1997. Bioorg. Med. Chem. 5, 49.
Kummer, J.L., et al. 1997. J. Biol. Chem. 272, 20490.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS06,GHS05
• 訊號詞: Danger
• 危險聲明: H301,H315,H318,H335
• 防範說明: P261 - P264 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
• 危險分類: Acute Tox. 3 Oral - Eye Dam. 1 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable