5.06419

Methysergide Maleate

• 同義詞: Methysergide Maleate, 5-HT Serotonin Receptor Antagonsit, Methysergide Maleate, UML-491
• 經驗公式（希爾表示法）: C₂₁H₂₇N₃O₂ · xC₄H₄O₄
• CAS號碼: 129-49-7
• 分子量：: 353.46 (free base basis)
• MDL號碼: MFCD00083185
• 分類程式碼代碼: 12352200

屬性

• 化驗: ≥99% (HPLC)
• 品質等級: 100
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: off-white
• 溶解度: water: 10 mM
• 儲存溫度: 2-8°C
• InChI: 1S/C21H27N3O2.C4H4O4/c1-4-15(12-25)22-21(26)14-8-17-16-6-5-7-18-20(16)13(10-23(18)2)9-19(17)24(3)11-14;5-3(6)1-2-4(7)8/h5-8,10,14-15,19,25H,4,9,11-12H2,1-3H3,(H,22,26);1-2H,(H,5,6)(H,7,8)/b;2-1-/t14-,15+,19-;/m1./s1
• InChI 密鑰: LWYXFDXUMVEZKS-ZVFOLQIPSA-N

描述

一般說明

An antagonist of the 5-HT_2B (pki = 8.0-9.4) and 5-HT_2C (pki = 8.6-9.1) receptor. At the 5-HT_1A and some other 5-HT receptors it serves as a partial agonist. It is known to have partial agonist effects on other 5-HT receptors as well. In neuronal and platelet culture, Methysergide blocks serotonin action with an IC₅₀ = 18 µM. Originally developed in the 1960′s as a migraine/cluster headache treatment, but discontinued due to significant physiological and pyschotropic side effects. Methysergide is still actively used in research as a 5-HT₂ receptor antagonist in both in vivo and in vitro experiments.

生化／生理作用

Primary Target
5-HT

警告

Toxicity: Toxic (F)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Matsuta, Y. et al. 2013. Exp. Neurol.247, 250.
IUHPAR Database 2013.

Shad, K.F., Saeed, S.A. 2007. Exp. Brain Res.183, 411.

Knight, A.R. et al. 2004. Naunyn Schmiedebergs Arch. Pharmacol.370, 114.

Saxena, P.R and Lawang, A. 1985. Arch. Int. Pharmacodyn. Ther.277, 235.
Colpaert, F. C. et al. 1979. Eur. J. Pharmacol.58, 505.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS06
• 訊號詞: Danger
• 危險聲明: H301
• 防範說明: P264 - P270 - P301 + P310 - P405 - P501
• 危險分類: Acute Tox. 3 Oral
• 儲存類別代碼: 6.1C - Combustible, acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable