5.05732

GBR 12909 Dihydrochloride

• 同義詞: GBR 12909 Dihydrochloride, 1-(2-Bis(4-fluorophenyl)methoxy)ethyl)-4-(3-phenylpropyl)piperazine Hydrochloride, Dopamine Active Transporter Inhibitor, GBR 12909, DAT Inhibitor, GBR 12909, GBR12909
• 經驗公式（希爾表示法）: C₂₈H₃₂F₂N₂O · 2HCl
• CAS號碼: 67469-78-7
• 分子量：: 523.49
• MDL號碼: MFCD00055193
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 化驗: ≥98% (HPLC)
• 品質等級: 100
• 形狀: solid
• 效力: 1 nM K_i
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white to off-white
• 溶解度: DMSO: 100 mM
• 儲存溫度: 2-8°C
• SMILES 字串: Fc1ccc(cc1)C(OCCN3CCN(CC3)CCCc4ccccc4)c2ccc(cc2)F.[Cl-].[Cl-].[H+].[H+]
• InChI: 1S/C28H32F2N2O.2ClH/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23;;/h1-3,5-6,8-15,28H,4,7,16-22H2;2*1H
• InChI 密鑰: MIBSKSYCRFWIRU-UHFFFAOYSA-N

描述

一般說明

A potent inhibitor of dopamine active transporter (DAT, K_i = 1 nM, IC₅₀ = 40 and 51 nM) with >100 fold selectivity over noradrenalin and 5-HT re-uptake transporter. Shown to produce behavioral profile in mice for bipolar mania disease model and ADHD disease models.

生化／生理作用

Primary Target
DAT

警告

Toxicity: Standard Handling (A)

準備報告

Slight warming is required for complete solubilization.

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Young, J. et al. 2010. Psychopharm.208, 443.

Hewitt, K., et al. 2009. Neuropharm.57, 678.
Prisinzano, T. et al. 2002. J. Med. Chem.45, 4371.
Andersen, P., et al. 1989. Eur. J. Pharmacol.166, 493.
Heikkila, R., et al. 1984. Eur. J. Pharmacol.103, 142.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable