492030

NS 2028

Potent, specific, and irreversible inhibitor of soluble guanylyl cyclase.

• 同義詞: NS 2028, 4H-8-Bromo-1,2,4-oxadiazolo(3,4-d)benz(b)(1,4)oxazin-1-one
• 經驗公式（希爾表示法）: C₉H₅BrN₂O₃
• CAS號碼: 204326-43-2
• 分子量：: 269.05
• MDL號碼: MFCD01530052
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥98% (NMR)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated
• 顏色: white to off-white
• 溶解度: chloroform: 1 mg/mL; DMSO: 5 mg/mL; ethanol: 5 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C9H5BrN2O3/c10-5-1-2-7-6(3-5)12-8(4-14-7)11-15-9(12)13/h1-3H,4H2
• InChI 密鑰: MUDRLQRJCGJJTB-UHFFFAOYSA-N

描述

一般說明

Potent, specific, and irreversible inhibitor of soluble guanylyl cyclase (IC₅₀ = 30 nM for basal and 200 nM for NO-stimulated enzyme activity; IC₅₀ = 17 nM for S-nitrosoglutathione-enhanced soluble guanylyl cyclase activity in homogenates of mouse cerebellum).

生化／生理作用

Cell permeable: no

Primary Target
basal soluble guanylyl cyclase

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 30 nM for basal and 200 nM for NO-stimulated enzyme activity; 17 nM for S-nitrosoglutathione-enhanced soluble guanylyl cyclase activity in homogenates of mouse cerebellum

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C) for long-term storage. DMSO stock solutions are stable for up to 1 month at -20°C and for ~8 h at 4°C. Avoid freeze/thaw cycles of solutions.

其他說明

Fleming, I., et al. 1999. Proc. Natl. Acad. Sci. USA 96, 1123.
Olesen, S.P., et al. 1998. Br. J. Pharmacol. 123, 299.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable