481409

PTEN, His-Tag^® and S-Tag, Human Recombinant, S. frugiperda

• 同義詞: Phosphatase and Tensin Homolog Deleted on Chromosome 10
• 分類程式碼代碼: 12352202
• NACRES: NA.42

屬性

• 化驗: ≥80% (SDS-PAGE)
• 品質等級: 100
• 形狀: liquid
• 比活性: ≥75 units/mg protein
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 運輸包裝: wet ice
• 儲存溫度: −70°C

描述

一般說明

Full-length, recombinant, human PTEN (GenBank target symbol = PTEN, ACC No. BC_005821) fused at N-terminus to a His•Tag and S•Tag sequences and expressed in S. frugiperda insect cells. PTEN is a tumor suppressor that is frequently found mutated in human cancers. It serves as a lipid phosphatase and negative regulator of the PI-3K/Akt pathway. Absence of functional PTEN results in constitutive activation of Akt and mTOR kinases.

包裝

Please refer to vial label for lot-specific concentration.

警告

Toxicity: Standard Handling (A)

單位定義

One unit is defined as the amount of enzyme required to liberate 1 nmol phosphate from PIP₃ per min at 37°C.

外觀

In 150 mM NaCl, 50 mM Tris-HCl, 5 mM DTT, 1 mM EDTA, 50% glycerol, pH 7.5.

重構

Following initial thaw, aliquot and freeze (-70°C).

其他說明

Harrington, L.S., et al. 2005. Trends Biochem. Sci.30, 35.
Osaki, M., et al. 2004. Apoptosis9, 667.
Lennon, G., et al. 1996. Genomics33, 151.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

HIS TAG is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable