480066
Necrostatin-1, Inactive Control
A cell-permeable N-demethylated thiohydantoin analog of Nec-1 that is devoid of anti-necroptotic properties and serves as a suitable inactive control.
同義詞:
Necrostatin-1, Inactive Control, 5-(Indol-3-ylmethyl)-2-thiohydantoin, Nec-1i
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About This Item
推薦產品
品質等級
化驗
≥95% (HPLC)
形狀
crystalline solid
製造商／商標名
Calbiochem®
儲存條件
OK to freeze
protect from light
顏色
light yellow
溶解度
DMSO: 10 mg/mL
methanol: 5 mg/mL
運輸包裝
ambient
儲存溫度
2-8°C
InChI
1S/C12H11N3OS/c16-11-10(14-12(17)15-11)5-7-6-13-9-4-2-1-3-8(7)9/h1-4,6,10,13H,5H2,(H2,14,15,16,17)
InChI 密鑰
MPLRRPKKFHUEEL-UHFFFAOYSA-N
一般說明
A cell-permeable N-demethylated thiohydantoin analog of Nec-1 (Cat. No. 480065) that is devoid of anti-necroptotic properties and serves as a suitable inactive control.
Note: This inactive inhibitor of necrosis should not be used in high concentration.
Note: This inactive inhibitor of necrosis should not be used in high concentration.
A cell-permeable N-demethylated thiohydantoin analog of Nec-1 (Cat. No. 480065) that is devoid of anti-necroptotic properties and serves as a suitable inactive control.
Note: This inactive inhibitor of necrosis should not be used in high concentration.
Note: This inactive inhibitor of necrosis should not be used in high concentration.
生化／生理作用
Cell permeable: yes
Primary Target
Inactive control for Nec-1 (Cat. No. 480065)
Inactive control for Nec-1 (Cat. No. 480065)
Product does not compete with ATP.
Reversible: no
包裝
Packaged under inert gas
警告
Toxicity: Standard Handling (A)
重構
Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
其他說明
Takahashi et al. 2012. Cell Death and Disease3, e437.
Degterev, A., et al. 2005. Nat. Chem. Biol.1, 112.
Degterev, A., et al. 2005. Nat. Chem. Biol.1, 112.
法律資訊
CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 1
閃點（°F）
Not applicable
閃點（°C）
Not applicable
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
N Takahashi et al.
Cell death & disease, 3, e437-e437 (2012-11-30)
Necrostatin-1 (Nec-1) is widely used in disease models to examine the contribution of receptor-interacting protein kinase (RIPK) 1 in cell death and inflammation. We studied three Nec-1 analogs: Nec-1, the active inhibitor of RIPK1, Nec-1 inactive (Nec-1i), its inactive variant
Alexei Degterev et al.
Nature chemical biology, 1(2), 112-119 (2006-01-13)
The mechanism of apoptosis has been extensively characterized over the past decade, but little is known about alternative forms of regulated cell death. Although stimulation of the Fas/TNFR receptor family triggers a canonical 'extrinsic' apoptosis pathway, we demonstrated that in
我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.
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