422712

KN-93

InSolution, ≥95%, A cell-permeable, competitive inhibitor of Ca²⁺/calmodulin-dependent protein kinase II

• 同義詞: InSolution KN-93
• 經驗公式（希爾表示法）: C₂₆H₂₉ClN₂O₄S
• CAS號碼: 139298-40-1
• 分子量：: 501.04
• MDL號碼: MFCD03788201
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: liquid
• 效力: 370 nM K_i
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic); protect from light
• 運輸包裝: wet ice
• 儲存溫度: −20°C
• InChI: 1S/C26H29ClN2O4S/c1-28(17-5-6-21-9-11-23(27)12-10-21)20-22-7-3-4-8-26(22)29(18-19-30)34(31,32)25-15-13-24(33-2)14-16-25/h3-16,30H,17-20H2,1-2H3/b6-5+
• InChI 密鑰: LLLQTDSSHZREGW-AATRIKPKSA-N

描述

一般說明

A cell-permeable, competitive inhibitor of Ca²⁺/calmodulin-dependent protein kinase II (K_i = 370 nM). Selectively binds to the Calmodulin (CaM) binding site of the enzyme and prevents the association of CaM with CaM Kinase II. Inhibits glucose-induced and forskolin-stimulated insulin release from isolated pancreatic islets. Has no significant effect on protein kinase A activity. Induces G₁ cell cycle arrest and apoptosis in NIH 3T3 cells.

生化／生理作用

Cell permeable: yes

Primary Target
cam kinase 2

Product does not compete with ATP.

Reversible: yes

包裝

Packaged under inert gas

警告

Toxicity: Irritant (B)

外觀

A 5 mM (1 mg/399 µl) solution of KN-93 (Cat. No. 422708) in DMSO.

重構

Following initial thaw aliquot and freeze (-20°C).

其他說明

Fan, G.H., et al. 1999. Mol. Pharmacol.56, 39.
Tombes, R.M., et al. 1995. Cell Growth Differentiation6, 1063.
Chen, C., et al. 1994. Science266, 291.
Mamiya, N., et al. 1993. Biochem. Biophys. Res. Commun.195, 608.
Niki, I., et al. 1993. Biochem. Biophys. Res. Commun.191, 255.
Sumi, M., et al. 1991. Biochem. Biophys. Res. Commun.181, 968.
Tokumitsu, H., et al. 1990. J. Biol. Chem.265, 4315.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany