341209

EUK-8

A synthetic salen-manganese complex with high superoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities.

• 同義詞: EUK-8
• 經驗公式（希爾表示法）: C₁₆H₁₄ClMnN₂O₂
• CAS號碼: 53177-12-1
• 分子量：: 356.69
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥90% (elemental analysis)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: dark brown
• 溶解度: DMSO: 20 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C

描述

一般說明

A synthetic salen-manganese complex with high superoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities. Shown to have protective effects in numerous models for disease processes associated with oxidative stress, including inflammation, cardiovascular diseases, acute critical illness, autoimmune diseases, and neurological disorders. Useful in preventing cardiac damage caused by ischemic reperfusion. Also prevents β-amyloid peptide (Aβ)-induced free radical formation and lipid peroxidation. Imparts protection against Aβ₄₀ and Aβ₄₂ toxicity in hippocampal cultures.

A synthetic salen-manganese complex with high superoxide dismutase (SOD), catalase, and oxyradical scavenger activities. Shown to have protective effects in numerous models for disease processes associated with oxidative stress, including inflammation, cardiovascular diseases, acute critical illness, autoimmune diseases, and neurological disorders. Useful in preventing cardiac damage caused by ischemic reperfusion. Also prevents β-amyloid peptide (Aβ)-induced free radical formation and lipid peroxidation and imparts protection against Aβ₄₀ and Aβ₄₂ toxicity in hippocampal cultures.

生化／生理作用

Cell permeable: no

Primary Target
Superoxide dismutase (SOD) and catalase-mimic activities, and oxyradical scavenging activities

Product does not compete with ATP.

Reversible: no

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 weeks at -20°C.

其他說明

Colparet, E. E. and Lefebure, R. A. 2000. Br. J. Pharmacol.130, 359.
Brandier, C., et al. 1997. J. Vasc. Res. 34, 49.
Doctrow, S.R., et al. 1997. Adv. Pharmacol. 38, 247.
Bruce, A.J., et al. 1996. Proc. Natl. Acad. Sci. USA 93, 2312.
Pucheu, S., et al. 1996. Cardiovasc. Drug Ther. 10, 331.
Baudry, M., et al. 1993. Biochem. Biophys. Res. Commun. 192, 964.

法律資訊

Not available for sale in Africa, Australia, Great Britain, Europe, Latvia, New Zealand, and the United States.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 2