325001

Epothilone B, Synthetic

A structural analog of Epothilone A with similar biological properties.

• 同義詞: Epothilone B, Synthetic, EpoB
• 經驗公式（希爾表示法）: C₂₇H₄₁NO₆S
• CAS號碼: 152044-54-7
• 分子量：: 507.68
• MDL號碼: MFCD02101921
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥99% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; protect from light
• 顏色: white to off-white
• 溶解度: DMSO: 10 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C
• InChI: 1S/C27H41NO6S/c1-15-9-8-10-27(7)22(34-27)12-20(16(2)11-19-14-35-18(4)28-19)33-23(30)13-21(29)26(5,6)25(32)17(3)24(15)31/h11,14-15,17,20-22,24,29,31H,8-10,12-13H2,1-7H3/b16-11+/t15-,17+,20-,21-,22-,24-,27+/m0/s1
• InChI 密鑰: QXRSDHAAWVKZLJ-PVYNADRNSA-N

描述

一般說明

A structural analog of Epothilone A (Cat. No. 325000) with similar biological properties. However, EpoB is about 10-fold more potent than EpoA against P-glycoprotein-expressing multidrug resistant (MDR) cells (IC₅₀ = 2 nM for MDR CCRF-CEM/VBL₁₀₀ cells).

A structural analog of Epothilone A (Cat. No. 325000) with similar biological properties. However, EpoB is about 10-fold more potent than EpoA against P-glycoprotein-expressing multi drug resistant (MDR) cells (IC₅₀ = 2 nM for MDR CCRF-CEM/VBL₁₀₀ cells).

生化／生理作用

Cell permeable: no

Primary Target
P-glycoprotein-expressing multidrug resistant (MDR) cells

Product does not compete with ATP.

Reversible: no

Target IC₅₀: 2 nM for MDR CCRF-CEM/VBL100 cells

警告

Toxicity: Toxic & Carcinogenic / Teratogenic (G)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for 3 months at -20°C.

其他說明

Due to the nature of the Hazardous Materials in this shipment, additional shipping charges may be applied to your order. Certain sizes may be exempt from the additional hazardous materials shipping charges. Please contact your local sales office for more information regarding these charges.

Giannakakou, P., et al. 2000. Proc. Natl. Acad. Sci. USA97, 2904.
Chou, T.-C., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 9642.
Kowalski, R.J., et al. 1997. J. Biol. Chem. 272, 2534.
Muhlradt, P.F., and Sasse, F. 1997. Cancer Res. 57, 3344.
Nicolaou, K.C., et al. 1997. Nature 387, 268.
Bollag, D.M., et al. 1995. Cancer Res. 55, 2325.

法律資訊

Not available for sale in Germany.

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable