300270

PARP Inhibitor III, DPQ

The PARP Inhibitor III, DPQ, also referenced under CAS 129075-73-6, controls the biological activity of PARP. This small molecule/inhibitor is primarily used for Cell Structure applications.

• 同義詞: PARP Inhibitor III, DPQ, 3,4-Dihydro-5[4-(1-piperindinyl)butoxy]-1(2H)-isoquinoline
• 經驗公式（希爾表示法）: C₁₈H₂₆N₂O₂
• CAS號碼: 129075-73-6
• 分子量：: 302.41
• MDL號碼: MFCD01866274
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥90% (HPLC)
• 形狀: solid
• 效力: 40 nM IC₅₀
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze
• 顏色: off-white
• 溶解度: DMSO: 5 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C
• SMILES 字串: N3(CCCCC3)CCCCOc1c2c(ccc1)C(=O)NCC2
• InChI: 1S/C18H26N2O2/c21-18-16-7-6-8-17(15(16)9-10-19-18)22-14-5-4-13-20-11-2-1-3-12-20/h6-8H,1-5,9-14H2,(H,19,21)
• InChI 密鑰: RVOUDNBEIXGHJY-UHFFFAOYSA-N

描述

一般說明

A potent and selective inhibitor of poly(ADP-ribose) polymerase (PARP; IC₅₀ = 40 nM). Significantly reduces infarcet volume in rat focual cerebrale ischemia model.

A very potent and selective poly(ADP-ribose)polymerase (PARP) inhibitor (IC₅₀ = 40 nM). Significantly reduces infarcet volume in rat focual cerebrale ischemia model.

生化／生理作用

Cell permeable: no

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Harmful (C)

其他說明

Eliasson, M.J., et al. 1997. Nat. Med. 3, 1089.
Takahashi, K., et al. 1997. J. Cereb. Blood Flow Metabl. 17, 1137.
Suto, M.J., et al. 1991. Anticancer Drug Des. 6, 107.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3