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Merck
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重要文件

238100

Sigma-Aldrich

CRM1 Inhibitor III

The CRM1 Inhibitor III controls the biological activity of CRM1. This small molecule/inhibitor is primarily used for Cell Structure applications.

同義詞:

CRM1 Inhibitor III, (Z)-But-2-enedioic acid (4ʹ-bromophenyl)amide (3ʹʹ-chlorophenyl)amide, Chromosome Region Maintenance 1 ProteinInhibitor III, Exportin 1 Inhibitor III, XPO1 Inhibitor III

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About This Item

經驗公式(希爾表示法):
C16H12BrClN2O2
CAS號碼:
分子量::
379.64
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.28

品質等級

化驗

≥95% (HPLC)

形狀

powder

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
protect from light

顏色

yellow

溶解度

DMSO: 100 mg/mL

運輸包裝

wet ice

儲存溫度

2-8°C

SMILES 字串

O=C(NC1=CC=CC(Cl)=C1)/C=C\C(NC2=CC=C(Br)C=C2)=O

一般說明

A cell-permeable butenediamide compound that acts as a potent, active site cysteine reactive irreversible inhibitor of CRM1/exportin 1. Shown to selectively repress agonist-mediated nuclear export of HDAC4/5, Rev and NFAT proteins in neonatal rat ventricular myocytes (NRVMs; EC50 = 2.2 and 3.5 nM for GFP-HDAC5 and GFP-HIV Rev) and suppress hypertrophic growth of NRVMs (EC50 = 52 nM for ANF expression inhibition) with negligible effect either on the phosphorylation of HDAC5 or on the kinase activities of PKD and CaMKII at 1 µM.

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Monovich, L., et al. 2009. Biochim Biophys Acta.1789, 422.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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