23-055-M

Cardiac Troponin I, 10 µg

Full length, recombinant human Cardiac Troponin I. N-terminal c-Myc, GST-tagged. For use in Enzyme Assays. Functions as a substrate in ubiquitination assays.

• 同義詞: Troponin I, cardiac muscle, TNNI3, TNNC1
• 分類程式碼代碼: 12352202
• eCl@ss: 32160405
• NACRES: NA.41

屬性

• 生物源: human
• 品質等級: 100; 300
• 重組細胞: expressed in baculovirus infected Sf21 cells
• 製造商／商標名: Upstate^®
• 技術: activity assay: suitable
• NCBI登錄號: NM_000363

描述

一般說明

Troponin is a complex of three regulatory proteins (Troponin I, Troponin T and Troponin C). It is located on the actin filament and is essential for the calcium-mediated regulation of skeletal and cardiac muscle contraction. There are tissue-specific isoforms of Troponin I, T and C and two subtypes (Cardiac Troponin I and T) are released when the heart muscle has been damaged, such as during a heart attack. The more damage there is to the heart, the greater the amount of Troponin I and T there will be in the blood and currently, Cardiac Troponin I and T are used as the preferred biochemical markers for the diagnosis of myocardial infarction. It has also been demonstrated that Cardiac Troponin I is targeted for degradation by MuRF1, an E3 ubiquitin ligase that has been linked to muscle atrophy

應用

Ubiquitination Cascade Comoponent: Substrate

外觀

Purified using immobilized metal affinity chromatography.

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 象形圖: GHS07
• 訊號詞: Warning
• 危險聲明: H317
• 防範說明: P261 - P272 - P280 - P302 + P352 - P333 + P313 - P362 + P364
• 危險分類: Skin Sens. 1
• 儲存類別代碼: 12 - Non Combustible Liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable