219381

Cathepsin K Inhibitor III

The Cathepsin K Inhibitor III controls the biological activity of Cathepsin K. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

• 同義詞: Cathepsin K Inhibitor III, Inhibitor I, 1-(N-Benzyloxycarbonyl-leucyl)-5-(phenylalanyl-leucyl)carbohydrazide, Z-L-NHNHCONHNH-LF-NH₂
• 經驗公式（希爾表示法）: C₃₀H₄₃N₇O₆
• 分子量：: 597.71
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥97% (HPLC)
• 形狀: lyophilized solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic)
• 顏色: white
• 溶解度: DMSO: 1 mg/mL
• 運輸包裝: wet ice
• 儲存溫度: −20°C

描述

一般說明

A cell-permeable peptidyl bis-carbohydrazide compound that acts as a potent, selective, and reversible inhibitor of cathepsin K (K_i,app = 9.7 nM). At higher concentrations, also inhibits the activities of cathepsin L, cathepsin B, and papain (K_i,app = 120 nM, 5.1 µM, and 2.3 µM, respectively). Completely blocks cathepsin K activity in primary human synovial fibroblast cultures at 1 µM.

A cell-permeable, potent, selective, reversible inhibitor of cathepsin K (K_i,app = 9.7 nM). At higher concentrations also inhibits the activities of cathepsin L, cathepsin B, and papain (K_i,app = 120 nM, 5.1 mM, and 2.3 µM, respectively). Reported to completely block cathepsin K activity in primary human synovial fibroblast cultures at a concentration of 1 µM.

生化／生理作用

Cell permeable: yes

Primary Target
Cathepsin K

Product does not compete with ATP.

Reversible: yes

Target K_i: 9.7 nM against cathepsin K

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

序列

H-Phe-Leu-NHNH-CO-NHNH-Leu-Z

外觀

Supplied as a trifluoroacetate salt.

重構

Following reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Wang, D., et al. 2002. Biochemistry41, 8849.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable