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Key Documents

208731

Sigma-Aldrich

Calpain Substrate II, Fluorogenic

Cyclic fluorogenic substrate for the quantitative determination of calpain -1 and -2.

同義詞:

Calpain Substrate II, Fluorogenic, Suc-LY-AMC

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About This Item

經驗公式(希爾表示法):
C29H31N3O7
CAS號碼:
分子量::
533.57
MDL號碼:
分類程式碼代碼:
12352200
NACRES:
NA.77

品質等級

化驗

≥95% (TLC)

形狀

solid

製造商/商標名

Calbiochem®

儲存條件

OK to freeze
desiccated
protect from light

顏色

off-white

溶解度

DMSO: soluble

螢光

λex ~380 nm
λem ~460 nm

運輸包裝

ambient

儲存溫度

−20°C

InChI

1S/C29H33N3O8/c1-4-16(2)27(32-24(34)11-12-25(35)36)29(39)31-22(14-18-5-8-20(33)9-6-18)28(38)30-19-7-10-21-17(3)13-26(37)40-23(21)15-19/h5-10,13,15-16,22,27,33H,4,11-12,14H2,1-3H3,(H,30,38)(H,31,39)(H,32,34)(H,35,36)/t16?,22?,27-/m0/s1

InChI 密鑰

VSWNAJAOJZXWBM-FTJGSZSVSA-N

一般說明

Cyclic fluorogenic substrate for the quantitative determination of calpain -1 and -2. Also suitable for measuring the peptidase activity of the 20S proteasome. Typical concentrations range from 10 - 100 µM, depending on assay conditions.
Fluorogenic substrate for the quantitative determination of porcine calpain I and II activity. Also serves as a substrate for other proteases including proteasome. (excitation wavelength: 380 nm; emission wavelength: 460 nm)

生化/生理作用

Cell permeable: no
Primary Target
Calpain -1 and -2
Product does not compete with ATP.
Reversible: no

警告

Toxicity: Standard Handling (A)

序列

Suc-Leu-Tyr-AMC

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.

其他說明

Seol, J.H., et al. 1989. FEBS Lett. 247, 197.
Woo, K.M., et al. 1989. J. Biol. Chem. 264, 2088.
Sasaki, T., et al. 1984. J. Biol. Chem.259, 12489.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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