203996

N-Butyldeoxynojirimycin, Hydrochloride

A non-hormonal, alkylated iminosugar that acts as a transition state analog inhibitor of ceramide-specific glycosyltransferases and ER α-glucosidases I and II.

• 同義詞: N-Butyldeoxynojirimycin, Hydrochloride, NB-DNJ, HCl, N-Butyl-DNJ, HCl
• 經驗公式（希爾表示法）: C₁₀H₂₁NO₄ · xHCl
• CAS號碼: 72599-27-0
• 分子量：: 219.28 (free base basis)
• MDL號碼: MFCD00272581
• 分類程式碼代碼: 12352200

屬性

• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic); protect from light
• 顏色: white
• 溶解度: water: 1 mg/mL
• 運輸包裝: ambient
• 儲存溫度: 2-8°C
• InChI: 1S/C10H21NO4/c1-2-3-4-11-5-8(13)10(15)9(14)7(11)6-12/h7-10,12-15H,2-6H2,1H3/t7-,8+,9-,10-/m1/s1
• InChI 密鑰: UQRORFVVSGFNRO-UTINFBMNSA-N

描述

一般說明

A non-hormonal, alkylated imino sugar that acts as a transition state analog inhibitor of ceramide-specific glycosyltransferases and ER α-glucosidases I and II. Displays broad-spectrum anti-viral effects by inhibiting the processing of viral surface glycoproteins. Shown to reversibly induce infertility in male mammals.

A non-hormonal, alkylated iminosugar that acts as a transition state analog inhibitor of ceramide-specific glycosyltransferases and ER α-glucosidases I and II. Displays a broad-spectrum anti-viral activity by aiding the misfolding of glycoproteins. Shown to reversibly induce infertility in male mammals. Does not inhibit cell proliferation.

Please note that the molecular weight for this compound is batch-specific due to variable water content.

生化／生理作用

Cell permeable: no

Primary Target
Ceramide-specific glycosyltransferases

Product does not compete with ATP.

Reversible: yes

包裝

Packaged under inert gas

警告

Toxicity: Standard Handling (A)

其他說明

Dwek, R.A., et al. 2002. Nat. Rev. Drug Discovery1, 65.
van der Spoel, A.C., et al. 2002. Proc. Natl. Acad. Sci. USA99, 17173.
Platt, F.M., et al. 1997. Science276, 428.
Block, T.M., et al. 1994. Proc. Natl. Acad. Sci. USA91, 2235.
Platt, F.M., et al. 1994. J. Biol. Chem.269, 8362.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable