178270

Apamin, Bee Venom

Polypeptide neurotoxin known to pass through the blood-brain barrier.

• 同義詞: Apamin, Bee Venom, CNCKAPETALCARRCQQH-NH₂
• 經驗公式（希爾表示法）: C₇₉H₁₃₁N₃₁O₂₄S₄
• CAS號碼: 24345-16-2
• 分子量：: 2027.34
• MDL號碼: MFCD00167944
• 分類程式碼代碼: 12352200
• NACRES: NA.77

屬性

• 描述: Merck USA index - 14, 725
• 品質等級: 100
• 化驗: ≥98% (HPLC)
• 形狀: solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic)
• 顏色: white, with dark tan cast
• 溶解度: 5% acetic acid: 2 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C
• SMILES 字串: S1SCC(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C3NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C4N(CCC4)C(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(CSSC3)N)CC(=O)N)C1)CCCCN)C)CCC(=O)O)C(O)C)C)CC(C)C)C)CCCN=C(N)N)CCCN=C(N)N)C(=O)NC(CCC(=O)N)C(=O)NC(CCC(=O)N)C(=O)NC(Cc2nc[nH]c2)C(
• InChI: 1S/C79H131N31O24S4/c1-35(2)26-49-70(127)107-51-31-136-135-30-41(81)63(120)105-50(28-57(84)114)71(128)108-53(73(130)99-42(12-7-8-22-80)64(121)96-38(5)77(134)110-25-11-15-54(110)75(132)102-47(18-21-58(115)116)69(126)109-59(39(6)111)76(133)95-37(4)62(119)104-49)33-138-137-32-52(106-66(123)44(14-10-24-92-79(88)89)98-65(122)43(13-9-23-91-78(86)87)97-61(118)36(3)94-72(51)129)74(131)101-45(16-19-55(82)112)67(124)100-46(17-20-56(83)113)68(125)103-48(60(85)117)27-40-29-90-34-93-40/h29,34-39,41-54,59,111H,7-28,30-33,80-81H2,1-6H3,(H2,82,112)(H2,83,113)(H2,84,114)(H2,85,117)(H,90,93)(H,94,129)(H,95,133)(H,96,121)(H,97,118)(H,98,122)(H,99,130)(H,100,124)(H,101,131)(H,102,132)(H,103,125)(H,104,119)(H,105,120)(H,106,123)(H,107,127)(H,108,128)(H,109,126)(H,115,116)(H4,86,87,91)(H4,88,89,92)
• InChI 密鑰: YVIIHEKJCKCXOB-UHFFFAOYSA-N

描述

一般說明

A polypeptide neurotoxin known to pass through the blood-brain barrier. Blocks the AHP-type Ca²⁺-activated K⁺ channel; however, it does not block the TEA and voltage-sensitive Ca²⁺-activated K⁺ channel. Known to induce the secretion of prolactin in a dose-dependent manner.

Polypeptide neurotoxin known to pass through the blood-brain barrier. Blocks the AHP-type Ca²⁺-activated K⁺ channel; does not block the TEA and voltage-sensitive Ca²⁺-activated K⁺ channel. Reported to induce neurodegeneration of Purkinje cells in rat brain. Known to induce the secretion of prolactin in a dose-dependent manner.

生化／生理作用

Cell permeable: no

Primary Target
AHP-type Ca2+-activated K+ channel

Product does not compete with ATP.

Reversible: no

警告

Toxicity: Harmful (C)

序列

H-Cys¹-Asn-Cys³-Lys-Ala-Pro-Glu-Thr-Ala-Leu-Cys¹¹-Ala-Arg-Arg-Cys¹⁵-Gln-Gln-His-NH₂ (disulfide bonds: 1 → 11; 3 → 15)

重構

Following reconstitution, aliquot and freeze (-20°C). Acetic acid stock solutions are stable for up to 3 days at -20°C.

其他說明

Mourre, C., et al. 1997. Brain Res. 778, 405.
Silva, E.G., et al. 1994. Br. J. Pharmacol. 113, 1022.
Wang, X., et al. 1994. Brain Res. 662, 83.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable