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Merck
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重要文件

14-629-M

Sigma-Aldrich

JAK3 Protein, active, 10 µg

Active, N-terminal His6-tagged, recombinant, human JAK3 amino acids 781-end, for use in Kinase Assays.

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About This Item

分類程式碼代碼:
12352202
eCl@ss:
32160405
NACRES:
NA.32

生物源

human

品質等級

100

重組細胞

expressed in baculovirus infected Sf21 cells

產品線

Upstate®

比活性

(For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.)

分子量

Mw 39.9 kDa

純化經由

(Ni2+/NTA-agarose)

物種活性

human

製造商／商標名

Upstate®

技術

activity assay: suitable (kinase)

登錄號

 (FUNCTION: SwissProt: P52333 # Tyrosine kinase of the non-receptor type, involved in the interleukin-2 and interleukin-4 signaling pathway. Phosphorylates STAT6, IRS1, IRS2 and PI3K. )
NM_000215.2

NCBI登錄號

NM_000215.2

UniProt登錄號

P52333

一般說明

N-terminal His6-tagged, recombinant, human JAK3 amino acids 781-end

應用

Research Category
Inflammation & Immunology

生化／生理作用

Protein Target: JAK3
Target Sub-Family: TK

包裝

Also available in 10 μg size and in bulk
Also available in 250 µg size --call for pricing and availability and reference catalog number 14-629M when ordering the 250 µg size.

品質

routinely evaluated by phosphorylation of 500μM JAK3tide (Catalog # 12-547)

標靶描述

JAK3

外觀

Ni2+/NTA-agarose

儲存和穩定性

6 months at -70°C

其他說明

For Specific Activity data, refer to the Certificate of Analysis for individual lots of this enzyme.

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

象形圖

Exclamation mark
GHS07

訊號詞

Warning

危險聲明

H317

危險分類

Skin Sens. 1

儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類（WGK）

WGK 2

閃點（°C）

Not applicable

分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。

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B A Witthuhn et al.
Nature, 370(6485), 153-157 (1994-07-14)
Many cytokines function through interaction with receptors of the cytokine receptor superfamily. Although lacking catalytic domains, cytokine receptors couple ligand binding to induction of protein tyrosine phosphorylation. Recent studies have shown that one or more of the Janus kinase family
J A Johnston et al.
Nature, 370(6485), 151-153 (1994-07-14)
Interleukin-2 is an autocrine growth factor for T cells which also activates other cells including B cells and natural killer cells. The subunits of the interleukin-2 receptor (IL-2R) lack intrinsic enzymatic activity, but protein tyrosine phosphorylation is a critical event

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