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Key Documents

13-107

Sigma-Aldrich

Core Histones

Highly pure core histones proteins (H2A, H2B, H3 and H4) including H1 purified from chicken erythrocytes, suitable as a substrate for histone modification assays (HAT, HDAC, DNMT) and nucleosome assembly studies.

同義詞:

Core Histone Proteins

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About This Item

分類程式碼代碼:
12352200
eCl@ss:
32160405
NACRES:
NA.32

生物源

chicken

製造商/商標名

Upstate®

技術

activity assay: suitable (histone acetyltransferase (HAT))

運輸包裝

dry ice

一般說明

Histones are a family of basic proteins that associate with DNA in the nucleus and help condense it into chromatin. Some histones function as spools for the thread-like DNA to wrap around forming a nucleosome. Each nucleosome is made of DNA wrapped around eight histone proteins that function like a spool and are called a histone octamer. Each histone octamer is composed of two copies each of the histone proteins H2A, H2B, H3, and H4. The chain of nucleosomes is then wrapped into a 30 nm spiral called a solenoid, where additional H1 histone proteins are associated with each nucleosome to maintain the chromosome structure.

應用

Core histones and histone H1, purified from chicken erythrocytes; suitable as a substrate for HAT assays; purity = 90%

品質

rountinely evaluated by immunoblot using Anti-Histone H3 (05-499) and Anti-Histone H4 (07-108)

外觀

Lyophilized

儲存和穩定性

Lyophilized: 2 years at -20°C; Rehydrated: 6 months at -70°C

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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AtFKBP53 is a histone chaperone required for repression of ribosomal RNA gene expression in Arabidopsis.
Hong Li,Sheng Luan
Cell research null
1-Aminoindan-1,5-dicarboxylic acid and (S)-(+)-2-(3'-carboxybicyclo[1.1.1] pentyl)-glycine, two mGlu1 receptor-preferring antagonists, reduce neuronal death in in vitro and in vivo models of cerebral ischaemia.
D E Pellegrini-Giampietro,A Cozzi,F Peruginelli,P Leonardi,E Meli,R Pellicciari,F Moroni
The European Journal of Neuroscience null
Analysis of nuclear receptor acetylation.
Chenguang Wang,Michael Powell,Lifeng Tian,Richard G Pestell
Methods in Molecular Biology null
Human erythropoietin-specific sites of monoclonal antibody-mediated neutralization.
M R Fibi,M Aslan,P Hintz-Obertreis,J U Pauly,M Gerken,G Luben,L Lauffer,B Siebold,W Stuber,G Nau
Blood null
Christina Schellenbacher et al.
Journal of virology, 83(19), 10085-10095 (2009-07-31)
The amino (N) terminus of the human papillomavirus (HPV) minor capsid protein L2 can induce low-titer, cross-neutralizing antibodies. The aim of this study was to improve immunogenicity of L2 peptides by surface display on highly ordered, self-assembled virus-like particles (VLP)

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