1.12374

Thrombin

from bovine plasma, 50 NIH units/mg dry wt

• 同義詞: Thrombin, Coagulation factor IIa, Fibrinogenase
• CAS號碼: 9002-04-4
• MDL號碼: MFCD00008719
• 分類程式碼代碼: 12352204
• 酶委員會索引編號: 232-648-7
• NACRES: NA.25

屬性

• 生物源: bovine plasma
• 品質等級: 200
• 形狀: solid
• 比活性: 50 NIH units/mg dry wt
• 儲存溫度: 2-8°C

描述

一般說明

Thrombin, a glycosylated sodium-activated type II enzyme, is also called coagulation factor IIa. It contains two anion-binding exosites, ABE-I and ABE-II. Thrombin exists as α, β, and γ isoforms at different stages of its generation. Bovine a-thrombin consists of a light chain (A chain) and a heavy chain (B chain). These two chains are joined by one disulfide bond.

應用

Thrombin has been used in flow cytometry analysis to investigate the basal activation level of circulating platelets in mice. It has also been used to coagulate the plasma and allow the organotypic slice to adhere to the coverslip during culturing.

生化／生理作用

Thrombin is a serine protease critical in the blood clotting process and activates clotting factors V, VIII, XI, and XII. It mediates the conversion of inactive plasma protein fibrinogen (factor I) into biologically active fibrin. Thrombin acts as a pro-coagulant and promotes platelet aggregation. It can also produce anti-coagulant effects. It is used to treat bleeding from capillaries and small venules. During vascular injury, thrombin is crucial for controlling the macrophages, neutrophils, monocytes, SMC, and dendritic cells.

分析報告

Appearance (colour): almost white
Appearance (description): powder
Activity (fibrinogen; pH 7.6; 37 °C): ≥ 50 U/mg

安全資訊

• 象形圖: GHS07,GHS08
• 訊號詞: Danger
• 危險聲明: H315 - H319 - H334 - H335
• 防範說明: P261 - P264 - P271 - P302 + P352 - P304 + P340 + P312 - P305 + P351 + P338
• 危險分類: Eye Irrit. 2 - Resp. Sens. 1 - Skin Irrit. 2 - STOT SE 3
• 標靶器官: Respiratory system
• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 1
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable