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本產品 | 05-1047 | 09-310 | 05-104 |
|---|---|---|---|
| antibody form purified immunoglobulin | antibody form purified antibody | antibody form affinity isolated antibody | antibody form purified antibody |
| clone polyclonal | clone 8G6.2, monoclonal | clone polyclonal | clone LA22, monoclonal |
| species reactivity rat, hamster, mouse, human | species reactivity rat, mouse, human | species reactivity human | species reactivity human |
| technique(s) immunoprecipitation (IP): suitable, western blot: suitable | technique(s) immunocytochemistry: suitable, immunohistochemistry: suitable, immunoprecipitation (IP): suitable, western blot: 1:2,000 using A431 cell lysate (used to detect EGFR), western blot: suitable | technique(s) ELISA: suitable, immunocytochemistry: suitable, western blot: suitable | technique(s) immunocytochemistry: suitable, immunoprecipitation (IP): suitable, western blot: suitable |
| shipped in ambient | shipped in wet ice | shipped in wet ice | shipped in dry ice |
特異性
Protein Phosphatase Methylesterase-1
免疫原
A mixture of two nickel agarose-purified, His6-tagged, bacterial expressed human Protein Phosphatase Methylesterase-1 (PME-1) fragments (residues 225-302 and 277-387). These two fragments represent the carboxyl-terminal portion of the protein.
應用
Research Category
Signaling
Neuroscience
Signaling
Neuroscience
Research Sub Category
Neurotransmitters & Receptors
Neurodegenerative Diseases
Neurotransmitters & Receptors
Neurodegenerative Diseases
This Anti-PP2A-methylesterase/PME-1 Antibody is validated for use in IP, WB for the detection of PP2A-methylesterase/PME-1.
品質
routinely evaluated by immunoblot on RIPA lysates from mouse 3T3 fibroblasts
標靶描述
44kDa
外觀
Protein A chromatography
0.1M Tris-glycine, pH 7.4, 0.15M NaCl, 0.05% sodium azide before the addition of glycerol to 30%
Format: Purified
儲存和穩定性
2 years at -20°C
分析報告
Control
Positive Antigen Control: Catalog #12-305, 3T3/A31 lysate. Add 2.5 μL of 2-mercapto-ethanol/100 μL of lysate and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced lysate per lane for minigels.
Positive Antigen Control: Catalog #12-305, 3T3/A31 lysate. Add 2.5 μL of 2-mercapto-ethanol/100 μL of lysate and boil for 5 minutes to reduce the preparation. Load 20 μg of reduced lysate per lane for minigels.
法律資訊
UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany
免責聲明
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
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儲存類別代碼
10 - Combustible liquids
水污染物質分類（WGK）
WGK 1
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
Single-pot enzymatic synthesis of Dicer-substrate siRNAs.
Guiley, KZ; Pratt, AJ; MacRae, IJ
Nucleic Acids Research null
Kesava Asam et al.
PloS one, 12(12), e0189413-e0189413 (2017-12-19)
Soluble forms of oligomeric beta-amyloid (Aβ) are thought to play a central role in Alzheimer's disease (AD). Transgenic manipulation of methylation of the serine/threonine protein phosphatase, PP2A, was recently shown to alter the sensitivity of mice to AD-related impairments resulting
Ha Yin Lee et al.
Science signaling, 11(512) (2018-01-11)
Cancer cells increase glucose metabolism to support aerobic glycolysis. However, only some cancer cells are acutely sensitive to glucose withdrawal, and the underlying mechanism of this selective sensitivity is unclear. We showed that glucose deprivation initiates a cell death pathway
Agnieszka Staniszewski et al.
The Journal of neuroscience : the official journal of the Society for Neuroscience, 40(23), 4596-4608 (2020-04-29)
Beta-amyloid (Aβ) is thought to play a critical role in Alzheimer's disease (AD), and application of soluble oligomeric forms of Aβ produces AD-like impairments in cognition and synaptic plasticity in experimental systems. We found previously that transgenic overexpression of the
E Ogris et al.
The Journal of biological chemistry, 274(20), 14382-14391 (1999-05-13)
Carboxymethylation of proteins is a highly conserved means of regulation in eukaryotic cells. The protein phosphatase 2A (PP2A) catalytic (C) subunit is reversibly methylated at its carboxyl terminus by specific methyltransferase and methylesterase enzymes which have been purified, but not
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