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Key Documents

05-521

Sigma-Aldrich

Anti-TRF2 Antibody, clone 4A794

clone 4A794, Upstate®, from mouse

同義詞:

Anti-TRBF2, Anti-TRF2

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

mouse

品質等級

抗體表格

purified immunoglobulin

抗體產品種類

primary antibodies

無性繁殖

4A794, monoclonal

物種活性

rat, human

製造商/商標名

Upstate®

技術

immunocytochemistry: suitable
western blot: suitable

同型

IgG1

NCBI登錄號

UniProt登錄號

運輸包裝

dry ice

目標翻譯後修改

unmodified

基因資訊

human ... TERF2(7014)

一般說明

TRF2 is a ubiquitously expressed protein that is implicated in the control of telomere length. TRF2, like TRF1, contains a Myb-related DNA binding motif. It binds to duplex TTAGGG repeats and is localised to all human telomeres in metaphase chromosomes. TRF2 is thought to protect chromosome ends by maintaining the correct structure at telomere termini. The use of mutant forms of TRF2 has implicated a role for TRF2 in the prevention of senescence in primary human cells. Recently, it has been shown that inhibition of TRF2 resulted in apoptosis in a subset of mammalian cell types. TRF2 is overexpressed in a number of human tumors and overexpression of TRF2 has been shown to be oncogenic in a mouse model of carcinogenesis.

特異性

Recognizes TRF2.

免疫原

His-tagged, fusion-protein, corresponding to full-length TRF2 (Telomeric Repeat binding Factor 2), expressed in baculovirus

應用

Anti-TRF2 Antibody, clone 4A794 is a Mouse Monoclonal Antibody for detection of TRF2 also known as Telomeric repeat-binding factor 1 & has been tested in ICC & WB.
Research Category
Epigenetics & Nuclear Function
Research Sub Category
Cell Cycle, DNA Replication & Repair

品質

routinely evaluated by immunoblot on RIPA lysate of human Jurkat cells, HeLa nuclear extract, or rat L6 RIPA cell lysate

標靶描述

66 kDa

外觀

Protein G Purified
Format: Purified
Protein G Purified mouse IgG1 in PBS with 0.05% sodium azide.

儲存和穩定性

Maintain for 2 years at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

分析報告

Control
Positive Antigen Control: Catalog #12-303, Jurkat cell lysate.

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

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您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

S K Manna et al.
Journal of immunology (Baltimore, Md. : 1950), 165(9), 4927-4934 (2000-10-25)
We and others have reported that IFN-alpha potentiates the apoptotic effects of TNF through a mechanism that is not understood. Because the nuclear transcription factors NF-kappaB and AP-1 have recently been reported to mediate anti-apoptosis and cell survival, we hypothesized
Manale El Idrissi et al.
Journal of experimental & clinical cancer research : CR, 32, 64-64 (2013-09-12)
Among the numerous genetic defects associated with hepatocarcinogenesis, telomere abnormalities appear to play a role both in tumor promotion and maintenance. Telomeres, the chromosome extremities, are protected by specific proteins, the shelterin complex and by additional factors. Besides telomerase dysregulation
Clara Lopes Novo et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 27(9), 3632-3642 (2013-06-05)
Telomeres are major regulators of genome stability and cell proliferation. A detailed understanding of the mechanisms involved in their maintenance is of foremost importance. Of those, telomere chromatin remodeling is probably the least studied; thus, we intended to explore the
Different telomere damage signaling pathways in human and mouse cells.
Agata Smogorzewska, Titia de Lange
The Embo Journal null
The cellular level of telomere dysfunction determines induction of senescence or apoptosis in vivo.
Andre Lechel, Ande Satyanarayana, Zhenyu Ju, Ruben R Plentz, Sonja Schaetzlein et al.
EMBO Reports null

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