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Key Documents

05-486

Sigma-Aldrich

抗-FADD抗体,克隆1F7

clone 1F7, Upstate®, from mouse

同義詞:

Anti-GIG3, Anti-IMD90, Anti-MORT1

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About This Item

分類程式碼代碼:
12352203
eCl@ss:
32160702
NACRES:
NA.41

生物源

mouse

品質等級

抗體表格

purified antibody

抗體產品種類

primary antibodies

無性繁殖

1F7, monoclonal

物種活性

mouse, human

製造商/商標名

Upstate®

技術

western blot: suitable

同型

IgG1

NCBI登錄號

UniProt登錄號

運輸包裝

dry ice

目標翻譯後修改

unmodified

基因資訊

human ... FADD(8772)
mouse ... Fadd(14082)

特異性

FADD

免疫原

对应人FADD的GST标记全长融合蛋白

應用

抗FADD抗体,克隆1F7,可检测FADD的水平 & 已出版 & 并经过验证可用于WB。
研究子类别
凋亡-附加
研究类别
细胞凋亡 & 癌症

品質

通过免疫印迹法对Jurkat细胞的RIPA裂解液进行了常规评估

標靶描述

28kDa

聯結

替代:04-1113

外觀

PBS,pH 7.2和50%甘油
形式:纯化
蛋白A层析

儲存和穩定性

在-20°C下可保存2年

分析報告

对照
阳性抗原对照:目录# 12-303,Jurkat细胞裂解液。

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

除非我们的产品目录或产品附带的其他公司文档另有说明,否则我们的产品仅供研究使用,不得用于任何其他目的,包括但不限于未经授权的商业用途、体外诊断用途、离体或体内治疗用途或任何类型的消费或应用于人类或动物。

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儲存類別代碼

12 - Non Combustible Liquids

水污染物質分類(WGK)

WGK 2

閃點(°F)

Not applicable

閃點(°C)

Not applicable


分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號,寫有 ‘Lot’或‘Batch’.。

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您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Simon Thompson et al.
The Journal of biological chemistry, 286(22), 19331-19339 (2011-04-12)
We have previously shown that the cell death-promoting protein Bcl-2-interacting mediator of cell death (Bim) is ubiquitinated and degraded following a neuroprotection-conferring episode of brief ischemia (preconditioning). Here, we identify the E3 ligase that ubiquitinates Bim in this model, using
Death domain mutagenesis of KILLER/DR5 reveals residues critical for apoptotic signaling
McDonald, E. R., 3rd, et al
The Journal of Biological Chemistry, 276, 14939-14945 (2001)
Hayley I Muendlein et al.
Nature communications, 12(1), 86-86 (2021-01-06)
Inflammation and cell death are closely linked arms of the host immune response to infection, which when carefully balanced ensure host survival. One example of this balance is the tightly regulated transition from TNFR1-associated pro-inflammatory complex I to pro-death complex
Prajwal Gurung et al.
Journal of immunology (Baltimore, Md. : 1950), 192(4), 1835-1846 (2014-01-24)
The Nlrp3 inflammasome is critical for host immunity, but the mechanisms controlling its activation are enigmatic. In this study, we show that loss of FADD or caspase-8 in a RIP3-deficient background, but not RIP3 deficiency alone, hampered transcriptional priming and
R K Subbarao Malireddi et al.
ImmunoHorizons, 4(12), 789-796 (2020-12-15)
Bacterial pathogens from the genus Yersinia cause fatal sepsis and gastritis in humans. Innate immune signaling and inflammatory cell death (pyroptosis, apoptosis, and necroptosis [PANoptosis]) serve as a first line of antimicrobial host defense. The receptor-interacting protein kinase 1 (RIPK1)

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