05-23-2101

Vasoactive Intestinal Peptide, Human, Porcine, and Rat

Acts as a mitogenic factor for embryonic neurons in the sympathetic nervous system.

• 同義詞: Vasoactive Intestinal Peptide, Human, Porcine, and Rat, VIP
• 經驗公式（希爾表示法）: C₁₄₇H₂₃₈N₄₄O₄₂S
• CAS號碼: 40077-57-4
• 分子量：: 3325.80
• MDL號碼: MFCD00167535
• 分類程式碼代碼: 12352202
• NACRES: NA.77

屬性

• 品質等級: 100
• 化驗: ≥95% (HPLC)
• 形狀: lyophilized solid
• 製造商／商標名: Calbiochem^®
• 儲存條件: OK to freeze; desiccated (hygroscopic)
• 顏色: white to off-white
• 溶解度: 5% acetic acid: 1 mg/mL
• 運輸包裝: ambient
• 儲存溫度: −20°C
• InChI: 1S/C147H237N43O43S/c1-18-75(12)115(142(229)180-96(56-72(6)7)131(218)183-104(145(232)233)63-110(155)200)188-139(226)106(68-192)185-134(221)101(62-109(154)199)177-130(217)95(55-71(4)5)174-132(219)97(58-81-37-41-84(195)42-38-81)175-125(212)88(33-23-26-49-149)167-123(210)89(34-24-27-50-150)171-140(227)113(73(8)9)186-118(205)76(13)164-121(208)93(47-53-234-17)170-127(214)92(45-46-107(152)197)169-122(209)87(32-22-25-48-148)166-124(211)90(35-28-51-161-146(156)157)168-129(216)94(54-70(2)3)173-126(213)91(36-29-52-162-147(158)159)172-143(230)116(78(15)193)189-136(223)98(59-82-39-43-85(196)44-40-82)176-133(220)100(61-108(153)198)178-135(222)103(65-112(203)204)182-144(231)117(79(16)194)190-137(224)99(57-80-30-20-19-21-31-80)181-141(228)114(74(10)11)187-119(206)77(14)165-128(215)102(64-111(201)202)179-138(225)105(67-191)184-120(207)86(151)60-83-66-160-69-163-83/h19-21,30-31,37-44,66,69-79,86-106,113-117,191-196H,18,22-29,32-36,45-65,67-68,148-151H2,1-17H3,(H2,152,197)(H2,153,198)(H2,154,199)(H2,155,200)(H,160,163)(H,164,208)(H,165,215)(H,166,211)(H,167,210)(H,168,216)(H,169,209)(H,170,214)(H,171,227)(H,172,230)(H,173,213)(H,174,219)(H,175,212)(H,176,220)(H,177,217)(H,178,222)(H,179,225)(H,180,229)(H,181,228)(H,182,231)(H,183,218)(H,184,207)(H,185,221)(H,186,205)(H,187,206)(H,188,226)(H,189,223)(H,190,224)(H,201,202)(H,203,204)(H,232,233)(H4,156,157,161)(H4,158,159,162)/t75-,76-,77-,78+,79+,86-,87-,88-,89-,90-,91-,92-,93-,94-,95-,96-,97-,98-,99-,100-,101-,102-,103-,104-,105-,106-,113-,114-,115-,116-,117-/m0/s1
• InChI 密鑰: VBUWHHLIZKOSMS-RIWXPGAOSA-N

描述

一般說明

Acts as a mitogenic factor for embryonic neurons in the sympathetic nervous system. Has powerful hypotensive and vasodilatory effects. Behaves either as a circulating hormone or as a neurotransmitter. Stimulates cAMP production in rat peritoneal macrophages. Inhibits the growth of human small-cell lung carcinoma (SCLC) both in vitro and in vivo, suggesting that it may be useful as a less toxic alternative to conventional chemotherapeutic agents in the treatment of SCLC. Nitric oxide stimulates the release of this peptide.

Acts as a mitogenic factor for embryonic neurons in the sympathetic nervous system. Has powerful hypotensive and vasodilatory effects. Behaves either as a circulating hormone or as a neurotransmitter. Stimulates cAMP production in rat peritoneal macrophages. Nitric oxide stimulates the release of this peptide. Inhibits human small-cell lung carcinoma (SCLC) in nude mice both in vitro and in vivo, suggesting that it may be useful as a less toxic alternative to conventional chemotherapeutic agents in the treatment of SCLC.

生化／生理作用

Cell permeable: no

Primary Target
Mitogenic factor for embryonic neurons

Product does not compete with ATP.

Reversible: no

包裝

Yes

警告

Toxicity: Harmful (C)

序列

H-His-Ser-Asp-Ala-Val-Phe-Thr-Asp-Asn-Tyr-Thr-Arg-Leu-Arg-Lys-Gln-Met-Ala-Val-Lys-Lys-Tyr-Leu-Asn-Ser-Ile-Leu-Asn-NH₂

外觀

Supplied as a trifluoroacetate salt.

重構

Following reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.

其他說明

Maruno, K., et al. 1998. Proc. Natl. Acad. Sci. USA 95, 14373.
Bakker, R., et al. 1993. Am. J. Physiol.264, R362.
Grider, J.R. 1993. Am. J. Physiol.264, G334.

法律資訊

CALBIOCHEM is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable