04-804

Anti-NFAT1 Antibody, clone 8G4.2

clone 8G4.2, Upstate^®, from mouse

• 同義詞: Nuclear factor of activated T-cells, cytoplasmic 2, NF-ATc2, NFATc2, NFAT pre-existing subunit, NF-Atp, T-cell transcription factor NFAT1
• 分類程式碼代碼: 12352203
• eCl@ss: 32160702
• NACRES: NA.41

屬性

• 生物源: mouse
• 品質等級: 100
• 抗體表格: purified antibody
• 抗體產品種類: primary antibodies
• 無性繁殖: 8G4.2, monoclonal
• 物種活性: rat, mouse, human
• 製造商／商標名: Upstate^®
• 技術: immunofluorescence: suitable; western blot: suitable
• 同型: IgMκ
• NCBI登錄號: NP_001129493.1
• UniProt登錄號: Q13469
• 運輸包裝: wet ice
• 目標翻譯後修改: unmodified
• 基因資訊: human ... NFATC2(4773)

描述

一般說明

NFAT (Nuclear Factor of Activated T-cells) is a family of transcription factors that are located in the cytoplasm in their inactive state. NFAT translocates to the nucleus upon stimulation of the T-cell receptor where it plays a key role in gene expression in immune response. NFAT is dephosphorylated and activated by the phosphatase PP2B/Calcineurin. This results in its nuclear localization and transcriptional activity. For NFAT1 (NFATC2, nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2), calcineurin is known to target the region between residues 114-126. Mutations in this region of NFAT1 result in its inability to de-phosphorylate and subsequent nuclear translocation. Upon activation, NFAT mediates the transcriptional induction of cytokines and other immuno-regulatory genes during immune responses, and is expressed in T-cells, B-cells, mast cells and NK cells.

特異性

Detects NFAT1.

Other species have not been tested.

免疫原

Epitope: N-term

GST-fusion protein corresponding to amino acids 1-297 of human NFAT1.

應用

Research Category
Signaling

Research Sub Category
Transcription Factors

This Anti-NFAT1 Antibody, clone 8G4.2 is validated for use in WB, IF for the detection of NFAT1.

品質

Routinely evaluated by Western Blot

標靶描述

120-140 kDa

外觀

Format: Purified

Purified mouse monoclonal in PBS with 0.05% NaN3.

儲存和穩定性

Stable for 1 year at 2-8°C from date of receipt.
Handling Recommendations: Upon receipt, and prior to removing the cap, centrifuge the vial and gently mix the solution.

其他說明

Concentration: Please refer to the Certificate of Analysis for the lot-specific concentration.

法律資訊

UPSTATE is a registered trademark of Merck KGaA, Darmstadt, Germany

免責聲明

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

安全資訊

• 儲存類別代碼: 10 - Combustible liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable