推薦產品
等級
certified reference material
品質等級
形狀
liquid
特點
Snap-N-Spike®/Snap-N-Shoot®
包裝
ampule of 1 mL
製造商／商標名
Cerilliant®
濃度
1.0 mg/mL in methanol
技術
gas chromatography (GC): suitable
liquid chromatography (LC): suitable
應用
clinical testing
格式
single component solution
儲存溫度
2-8°C
SMILES 字串
OCc1nnc2CN=C(c3ccccc3Cl)c4cc(Cl)ccc4-n12
InChI
1S/C17H12Cl2N4O/c18-10-5-6-14-12(7-10)17(11-3-1-2-4-13(11)19)20-8-15-21-22-16(9-24)23(14)15/h1-7,24H,8-9H2
InChI 密鑰
BHUYWUDMVCLHND-UHFFFAOYSA-N
尋找類似的產品？ 前往 產品比較指南
一般說明
α-羟基三唑仑是苯二氮卓类药物三唑仑（一种用于治疗严重失眠的药物）的主要尿液和血液代谢产物。该认证溶液标准品适用于临床毒理学、法医学分析、尿液药物检测或药物研究的 LC/MS 或 GC/MS 应用。
應用
- Pharmacokinetic analysis of benzodiazepines: alpha-Hydroxytriazolam solution is employed in the quantitation of benzodiazepines and their metabolites in biological fluids using liquid chromatography-tandem mass spectrometry, providing accurate pharmacokinetic profiles that are essential for clinical and forensic analysis (Zheng et al., 2018).
- Receptor binding studies: The application of high-purity alpha-Hydroxytriazolam in receptor binding studies enables researchers to elucidate the interaction mechanisms of benzodiazepine analogs at the molecular level, thereby enhancing the understanding of their pharmacological effects (Minegishi et al., 2021).
- Development of analytical methods: alpha-Hydroxytriazolam solution serves as a critical analytical standard in the development of robust assays for the detection and quantification of benzodiazepines in various matrices, facilitating advancements in toxicological and pharmacological research (Lahr et al., 2020).
- Forensic and clinical toxicology: Utilized in forensic science, alpha-Hydroxytriazolam solution aids in the rapid determination of benzodiazepines and their metabolites in urine samples, crucial for the accurate interpretation of toxicological data (Jeong et al., 2015).
- Scientific research in biochemistry: alpha-Hydroxytriazolam research compounds are vital for studying the metabolic pathways and degradation profiles of triazolam and related benzodiazepines, supporting biochemists in drug metabolism and pharmacokinetics research (Jin et al., 2011).
法律資訊
CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany
相關產品
產品號碼
描述
訂價
訊號詞
Danger
危險分類
Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1
儲存類別代碼
3 - Flammable liquids
水污染物質分類（WGK）
WGK 2
閃點（°F）
49.5 °F - closed cup
閃點（°C）
9.7 °C - closed cup
分析證明 (COA)
輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。
客戶也查看了
Qiran Sun et al.
Journal of analytical toxicology, 34(2), 89-94 (2010-03-13)
A sensitive liquid chromatography-tandem mass spectrometry method is presented for determination of triazolam and alpha-hydroxytriazolam in guinea pig hair after a single dose of triazolam. Eighteen guinea pigs were divided into three dosage groups (10, 100, and 500 microg/kg) and
F S Eberts et al.
Clinical pharmacology and therapeutics, 29(1), 81-93 (1981-01-01)
Triazolam (T) is a new, potent hypnotic with a short duration of action in man. After an 0.88-mg oral dose of T-14C in six male subjects, mean recovery of 14C radioactivity was 85% in urine and 8% in feces. The
Dong-Liang Lin et al.
Journal of analytical toxicology, 29(2), 118-123 (2005-05-21)
As an approved medicinal product and reportedly an abused substance that have been associated with death and "considered to be a factor...of impaired driving, sexual assault, and other violent crimes", triazolam is controlled at the same level (Level III) as
A D Fraser et al.
Journal of analytical toxicology, 16(6), 347-350 (1992-11-01)
Triazolam is a very short-acting triazolobenzodiazepine with sedative-hypnotic properties. Approximately 2% of an oral dose is excreted unchanged in the urine. The major urinary metabolite is alpha-hydroxytriazolam glucuronide (70% of the dose). The objective of this study was to characterize
Dora Farkas et al.
Journal of clinical pharmacology, 47(3), 286-294 (2007-02-27)
The effect of pomegranate juice (PJ) or grapefruit juice (GFJ) on CYP3A activity was studied in vitro and in healthy human volunteers. In human liver microsomes, the mean 50% inhibitory concentrations (IC(50)) for PJ and GFJ versus CYP3A (triazolam alpha-hydroxylation)
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