跳轉至內容
Merck
全部照片(1)

Key Documents

View All Documentation

T-068

Supelco

Tilidine hydrochloride solution

1.0 mg/mL in methanol (as free base), ampule of 1 mL, certified reference material, Cerilliant®

登入查看組織和合約定價
全部照片(1)

About This Item

經驗公式（希爾表示法）:
C17H23NO2 · HCl
CAS號碼:
27107-79-5
分子量：:
309.83
EC號碼:
200-659-6
MDL號碼:
MFCD01735084
分類程式碼代碼:
41116107
PubChem物質ID:
329826611
NACRES:
NA.24

等級

certified reference material

形狀

liquid

特點

Snap-N-Spike®/Snap-N-Shoot®

包裝

ampule of 1 mL

製造商／商標名

Cerilliant®

drug control

Narcotic Licence Schedule A (Switzerland); estupefaciente (Spain); Decreto Lei 15/93: Tabela IA (Portugal)

濃度

1.0 mg/mL in methanol (as free base)

技術

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

應用

forensics and toxicology

格式

single component solution

儲存溫度

−20°C

SMILES 字串

Cl.CCOC(=O)[C@@]1(CCC=C[C@H]1N(C)C)c2ccccc2

InChI

1S/C17H23NO2.ClH/c1-4-20-16(19)17(14-10-6-5-7-11-14)13-9-8-12-15(17)18(2)3;/h5-8,10-12,15H,4,9,13H2,1-3H3;1H/t15-,17+;/m1./s1

InChI 密鑰

MUWDJVKYGSDUSH-KALLACGZSA-N

相關類別

一般說明

Tilidine is a synthetic opioid analgesic used mainly in Germany, Switzerland and Belgium for treatment of moderate to severe pain, both acute and chronic. While tilidine is considered a moderately-potent opioid, its active metabolite nortilidine possesses analgesic effects roughly equivalent to that of morphine.

應用

  • Opioid Detection in Hair: Research demonstrated the application of liquid chromatography/tandem mass spectrometry for detecting opioids, including Tilidine, in hair samples from palliative care patients, offering insights into long-term drug use and compliance monitoring (Musshoff et al., 2007).

  • Drug Testing in Hair Analysis: An analytical technique using LC-ESI-MS/MS and MALDI-MS/MS imaging was utilized to distinguish between Tilidine intake and external contamination in segmental hair analysis, improving accuracy in drug testing scenarios (Poetzsch et al., 2015).

法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

訊號詞

Danger

危險分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

標靶器官

Eyes

儲存類別代碼

3 - Flammable liquids

水污染物質分類（WGK）

WGK 1

閃點（°F）

49.5 °F - closed cup

閃點（°C）

9.7 °C - closed cup

分析證明 (COA)

輸入產品批次/批號來搜索 分析證明 (COA)。在產品’s標籤上找到批次和批號，寫有 ‘Lot’或‘Batch’.。

已經擁有該產品？

您可以在文件庫中找到最近購買的產品相關文件。

存取文件庫

Barbara Grün et al.
British journal of clinical pharmacology, 74(5), 854-863 (2012-03-03)
The analgesic activity of tilidine is mediated by its active metabolite, nortilidine, which easily penetrates the blood-brain barrier and binds to the µ-opioid receptor as a potent agonist. Tilidine undergoes an extensive first-pass metabolism, which has been suggested to be
Isabel Wustrow et al.
Naunyn-Schmiedeberg's archives of pharmacology, 385(6), 633-639 (2012-02-22)
Tilidine exhibits the highest consumption of opioids in Germany. The prodrug is hepatically metabolised in a sequential N-demethylation reaction. Its primary metabolite nortilidine is a selective μ-opioid receptor agonist which can penetrate the blood-brain barrier. Cytochrome P450 isozymes (CYP) 3A4
[Not to change therapy unnecessarily! Step 2 opioids at first prescription are of advantage].
MMW Fortschritte der Medizin, 147(45), 63-63 (2005-12-03)
Johanna Weiss et al.
Naunyn-Schmiedeberg's archives of pharmacology, 378(3), 275-282 (2008-06-03)
Tilidine is one of the most widely used narcotics in Germany and Belgium. The compound's active metabolite nortilidine easily penetrates the blood-brain barrier and activates the mu-opioid receptor. Thus far, the enzymes involved in tilidine metabolism are unknown. Therefore, the
Paul J Fudala et al.
Drug and alcohol dependence, 83 Suppl 1, S40-S47 (2006-03-28)
Non-medical abuse of prescription opioid medications is not a new phenomenon, but such use has been increasing in recent years. Various methods have been used and continue to be developed in an effort to limit diversion and abuse of opioid
查看所有相關論文

我們的科學家團隊在所有研究領域都有豐富的經驗，包括生命科學、材料科學、化學合成、色譜、分析等.

聯絡技術服務