M-153

甲氨蝶呤-D_{3标准液 CRM} 溶液

100 μg/mL in methanol with 0.01N NaOH, ampule of 1 mL, certified reference material, Cerilliant^®

• 經驗公式（希爾表示法）: C₂₀H₁₉N₈O₅D₃
• CAS號碼: 432545-63-6
• 分子量：: 457.46
• EC號碼: 200-659-6
• 分類程式碼代碼: 41116107
• NACRES: NA.24

屬性

• 等級: certified reference material
• 形狀: liquid
• 特點: Snap-N-Spike^®/Snap-N-Shoot^®
• 包裝: ampule of 1 mL
• 製造商／商標名: Cerilliant^®
• 濃度: 100 μg/mL in methanol with 0.01N NaOH
• 技術: gas chromatography (GC): suitable; liquid chromatography (LC): suitable
• 應用: pharmaceutical (small molecule)
• 格式: single component solution
• 儲存溫度: −20°C
• SMILES 字串: [2H]C([2H])([2H])N(Cc1cnc2nc(N)nc(N)c2n1)c3ccc(cc3)C(=O)NC(CCC(O)=O)C(O)=O
• InChI: 1S/C20H22N8O5/c1-28(9-11-8-23-17-15(24-11)16(21)26-20(22)27-17)12-4-2-10(3-5-12)18(31)25-13(19(32)33)6-7-14(29)30/h2-5,8,13H,6-7,9H2,1H3,(H,25,31)(H,29,30)(H,32,33)(H4,21,22,23,26,27)/i1D3
• InChI 密鑰: FBOZXECLQNJBKD-FIBGUPNXSA-N

描述

一般說明

一个适用于通过 LC-MS/MS 对甲氨蝶呤患者血清样品进行治疗性药物监测分析的内标。甲氨蝶呤用于治疗癌症和自身免疫性疾病，是一种抗代谢物和抗叶酸药物，由临床实验室进行监控，以确保患者服用量维持在该药物的治疗范围内。Snap-N-Spike^® 解决方案格式可让实验室不需要对氨甲蝶呤等有害物质进行称重操作，显着降低处理剧毒粉末相关的职业暴露危害，并提供在使用前立即掺入所选基质的功能。

應用

• Application in leukemia research: Methotrexate-D₃ is utilized as an internal standard in LC-MS/MS analysis to monitor the bioavailability and metabolic pathways of thioguanosine and methylthioinosine in children with acute lymphoblastic leukemia, supporting its use in pediatric oncology and pharmacokinetics studies (Han et al., 2022).


• Enhancement of drug monitoring techniques: Employed in high-throughput MALDI-isotope dilution mass spectrometry, Methotrexate-D₃ allows for the ultrafast and selective quantification of methotrexate in human plasma, proving essential for optimizing therapeutic regimens in cancer treatment (Meesters et al., 2011).

法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany

Snap-N-Shoot is a registered trademark of Cerilliant Corporation

Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

安全資訊

• 象形圖: GHS02,GHS06,GHS08,GHS05
• 訊號詞: Danger
• 危險聲明: H225,H290,H301 + H311 + H331,H370
• 防範說明: P210 - P233 - P280 - P301 + P310 - P303 + P361 + P353 - P304 + P340 + P311
• 危險分類: Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - Met. Corr. 1 - STOT SE 1
• 標靶器官: Eyes,Central nervous system
• 儲存類別代碼: 3 - Flammable liquids
• 水污染物質分類（WGK）: WGK 2
• 閃點（°F）: 49.5 °F - closed cup
• 閃點（°C）: 9.7 °C - closed cup