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E-901

Supelco

艾司唑仑标准液 溶液

1.0 mg/mL in methanol, ampule of 1 mL, certified reference material, Cerilliant®

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About This Item

經驗公式（希爾表示法）:
C16H11ClN4
CAS號碼:
29975-16-4
分子量：:
294.74
EC號碼:
200-659-6
分類程式碼代碼:
41116107
NACRES:
NA.24

等級

certified reference material

品質等級

300

形狀

liquid

特點

Snap-N-Spike®/Snap-N-Shoot®

包裝

ampule of 1 mL

製造商／商標名

Cerilliant®

drug control

Narcotic Licence Schedule B (Switzerland); psicótropo (Spain); Decreto Lei 15/93: Tabela IV (Portugal)

濃度

1.0 mg/mL in methanol

技術

gas chromatography (GC): suitable
liquid chromatography (LC): suitable

應用

clinical testing

格式

single component solution

儲存溫度

−20°C

SMILES 字串

Clc1ccc-2c(c1)C(=NCc3nncn-23)c4ccccc4

InChI

1S/C16H11ClN4/c17-12-6-7-14-13(8-12)16(11-4-2-1-3-5-11)18-9-15-20-19-10-21(14)15/h1-8,10H,9H2

InChI 密鑰

CDCHDCWJMGXXRH-UHFFFAOYSA-N

基因資訊

human ... GABRA1(2554) , GABRA2(2555) , GABRA3(2556) , GABRA4(2557) , GABRA5(2558) , GABRA6(2559) , GABRB1(2560) , GABRB2(2561) , GABRB3(2562) , GABRD(2563) , GABRE(2564) , GABRG1(2565) , GABRG2(2566) , GABRG3(2567) , GABRP(2568) , GABRQ(55879)

相關類別

一般說明

CRM质量级别的Snap-N-Spike®溶液适合用作从法医分析和临床毒理学研究到尿液药物检测的各种LC/MS或GC/MS应用的校准品或对照品的起始材料。艾司唑仑是一种苯二氮卓类药物，可用于失眠症的短期治疗。艾司唑仑以ProSom或悠乐丁等商品名出售，经常被娱乐性滥用以达到高剂量或违反医生的建议而长期使用。

應用


  • Estazolam in environmental trace analysis: A study employing ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) detailed the detection of Estazolam among other psychotropic medications in environmental samples, underscoring the method′s precision and application in monitoring environmental contamination by pharmaceutical residues (Wang et al., 2024).

  • Estazolam and insomnia post-coronavirus disease: Research analyzed insomnia prevalence among COVID-19 survivors, identifying Estazolam as part of the therapeutic regimen. This study highlights the ongoing relevance of Estazolam in addressing sleep disorders associated with long-term recovery from significant health events (Lu et al., 2024).

  • Comparative analysis of Estazolam for post-stroke insomnia: A network meta-analysis compared various treatments for post-stroke insomnia, including Estazolam, providing insights into its effectiveness relative to other therapeutic options. This study contributes to understanding optimal treatment strategies for insomnia in post-stroke patients (Song et al., 2023).

法律資訊

CERILLIANT is a registered trademark of Merck KGaA, Darmstadt, Germany
Snap-N-Shoot is a registered trademark of Cerilliant Corporation
Snap-N-Spike is a registered trademark of Merck KGaA, Darmstadt, Germany

訊號詞

Danger

危險分類

Acute Tox. 3 Dermal - Acute Tox. 3 Inhalation - Acute Tox. 3 Oral - Flam. Liq. 2 - STOT SE 1

儲存類別代碼

3 - Flammable liquids

水污染物質分類（WGK）

WGK 1

閃點（°F）

49.5 °F - closed cup

閃點（°C）

9.7 °C - closed cup

分析證明 (COA)

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Yuan Tian et al.
Journal of pharmaceutical and biomedical analysis, 47(4-5), 899-906 (2008-05-13)
A simple, rapid, sensitive and selective liquid chromatographic-tandem mass spectrometric (LC-MS/MS) method was developed and validated for the quantification of rupatadine in human plasma using estazolam as internal standard (IS). Following liquid-liquid extraction, the analytes were separated using a mobile
Clinical efficacies of treating refractory insomnia patients with estazolam plus alternating current magnetic field.
Zhi-Zhong Wang et al.
Chinese medical journal, 125(17), 3175-3176 (2012-08-31)
Toshiaki Aoshima et al.
Progress in neuro-psychopharmacology & biological psychiatry, 27(3), 535-538 (2003-04-15)
The effects of the cytochrome P450 (CYP)2C19 genotype and cigarette smoking on the single oral dose pharmacokinetics and pharmacodynamics of estazolam were studied in 16 healthy male volunteers. The two mutated alleles (CYP2C19*2 and CYP2C19*3) causing absent CYP2C19 activity were
T Tadano et al.
Pharmacology, 62(3), 157-162 (2001-04-05)
Intraperitoneal injection of benzodiazepine receptor agonists (estazolam, zopiclone, triazolam: 0.03-0.24 mmol/kg) induces the head twitch response (HTR). The present study was undertaken to examine the possible participation of the serotonergic system in the mechanism of head twitches induced by benzodiazepine
Jun Bu et al.
Fa yi xue za zhi, 26(1), 30-32 (2010-03-18)
To study the relation between human blood estazolam concentration and neurobehavioral function. The neurobehavioral ability of 10 volunteers were measured with computer-administered neurobehavioral evaluation system-chinese3 (NES-C3) and SMART EquiTest system. The neurobehavioral ability and balance function declined 1 h later
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