推薦產品
形狀
liquid
包裝
pkg of 1 × 5 mg (with screw cap/argon/foil bag (870450O-5mg))
製造商／商標名
Avanti Research™ - A Croda Brand 870450O
脂質類型
bioactive lipids
phosphoglycerides
運輸包裝
dry ice
儲存溫度
−70°C
SMILES 字串
[H]C(CO)(OC(CCC/C=C\C/C=C\C/C=C\C/C=C\CCCCC)=O)CO
InChI
1S/C23H38O4/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-18-19-23(26)27-22(20-24)21-25/h6-7,9-10,12-13,15-16,22,24-25H,2-5,8,11,14,17-21H2,1H3/b7-6-,10-9-,13-12-,16-15-
InChI 密鑰
RCRCTBLIHCHWDZ-DOFZRALJSA-N
一般說明
2-花生四烯酰甘油（2-AG）是一种内源性大麻素，是CB1受体的内源性激动剂。与阿那达胺不同，2-AG在中央神经紧张的系统中以相对较高的水平存在。它是在小鼠和大鼠脑中发现的最丰富的单酰基甘油分子种类（~5-10 nmol/g组织）。在标准脂质提取条件下，由于其相对容易异构化为1-AG，因此脑组织中2-AG的检测变得复杂。与阿那达胺不同，2-AG的形成是钙依赖性的，并且由磷脂酶C（PLC）和二酰基甘油脂肪酶（DAGL）的活性介导。2-AG充当CB1受体的完全激动剂。在0.3 nM的浓度下，2-AG通过CB1受体依赖性机制诱导NG108-15神经母细胞瘤X胶质瘤细胞中细胞内游离钙的快速，瞬时增加。2-AG在体外被单酰基甘油脂肪酶（MAGL）、脂肪酸酰胺水解酶（FAAH）和未表征的丝氨酸水解酶ABHD6和ABHD12水解。
包裝
5 mL PTFE小瓶，带螺旋盖/氩气/铝箔袋（870450O-5mg）
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
12 - Non Combustible Liquids
水污染物質分類（WGK）
WGK 3
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The Journal of biological chemistry, 274(5), 2794-2801 (1999-01-23)
An endogenous cannabimimetic molecule, 2-arachidonoylglycerol, induces a rapid, transient increase in intracellular free Ca2+ concentrations in NG108-15 cells through a cannabinoid CB1 receptor-dependent mechanism. We examined the activities of 24 relevant compounds (2-arachidonoylglycerol, its structural analogues, and several synthetic cannabinoids).
Freek J Janssen et al.
Bioorganic & medicinal chemistry letters, 26(16), 3831-3837 (2016-07-11)
2-Arachidonoylglycerol (2-AG) is an endocannabinoid that activates the cannabinoid receptors type 1 and 2. It also serves as an important lipid precursor for the eicosanoid signaling pathway. Consequently, 2-AG is involved in many physiological functions, including anxiety, food intake, inflammation
Jonathan Z Long et al.
Nature chemical biology, 5(1), 37-44 (2008-11-26)
2-Arachidonoylglycerol (2-AG) and anandamide are endocannabinoids that activate the cannabinoid receptors CB1 and CB2. Endocannabinoid signaling is terminated by enzymatic hydrolysis, a process that for anandamide is mediated by fatty acid amide hydrolase (FAAH), and for 2-AG is thought to
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Scientific reports, 3, 2093-2093 (2013-06-29)
Endocannabinoids are small signaling lipids, with 2-arachidonoylglycerol (2-AG) implicated in modulating axonal growth and synaptic plasticity. The concept of short-range extracellular signaling by endocannabinoids is supported by the lack of trans-synaptic 2-AG signaling in mice lacking sn-1-diacylglycerol lipases (DAGLs), synthesizing
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