推薦產品
形狀
powder
包裝
pkg of 1 × 1 mg (860662P-1mg)
製造商／商標名
Avanti Research™ - A Croda Brand 860662P
脂質類型
sphingolipids
運輸包裝
dry ice
儲存溫度
−20°C
SMILES 字串
[H][C@](/C=C/CCCCCCCCCCCCCCC)(O)[C@]([NH3+])([H])COP([O-])(O)=O
InChI
1S/C20H42NO5P/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-20(22)19(21)18-26-27(23,24)25/h16-17,19-20,22H,2-15,18,21H2,1H3,(H2,23,24,25)/b17-16+/t19-,20+/m0/s1
InChI 密鑰
YUUWWSOTAGQJFW-YIVRLKKSSA-N
相關類別
一般說明
Sphingosine-1-phosphate (S1P) is a zwitterionic sphingolipid. It is found in insects, yeasts and plants. Sphingosine-1-Phosphate (d20:1) is a phosphorylated derivative of long chain base C20 sphingosine.
應用
Sphingosine-1-phosphate (S1P)-d7 has been used as a reference standard in liquid chromatography/tandem mass spectrometry analysis for quantitative analyses of S1P d20:1 in central nervous system of healthy mice and in human glioblastoma tissue.
生化／生理作用
Sphingosine-1-phosphate (S1P) is an important cellular metabolite and signaling lipid in animal cells. It aids in various physiological and cellular processes such as atherosclerosis, inflammation, immunity, tumorigenesis, and cell proliferation. S1P plays a vital role in mammalian brain and cardiac development. S1P d20:1 serves as a partial agonist at the S1P receptor 2 (S1P2). It has an ability to inhibit S1P d18:1‐mediated cyclooxygenase 2(COX2) induction.
包裝
5 mL Amber Glass Screw Cap Vial (860662P-1mg)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
儲存類別代碼
11 - Combustible Solids
水污染物質分類（WGK）
WGK 3
Henrik Fyrst et al.
Nature chemical biology, 6(7), 489-497 (2010-06-19)
Sphingolipids comprise a complex family of naturally occurring molecules that are enriched in lipid rafts and contribute to their unique biochemical properties. Membrane sphingolipids also serve as a reservoir for bioactive metabolites including sphingosine, ceramide, sphingosine-1-phosphate and ceramide-1-phosphate. Among these
Michael Maceyka et al.
Trends in cell biology, 22(1), 50-60 (2011-10-18)
The bioactive sphingolipid metabolite sphingosine-1-phosphate (S1P) is now recognized as a critical regulator of many physiological and pathophysiological processes, including cancer, atherosclerosis, diabetes and osteoporosis. S1P is produced in cells by two sphingosine kinase isoenzymes, SphK1 and SphK2. Many cells
Rajkumar Vutukuri et al.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 34(3), 3932-3942 (2020-01-17)
Sphingosine 1-phosphate (S1P) signaling influences numerous cell biological mechanisms such as differentiation, proliferation, survival, migration, and angiogenesis. Intriguingly, our current knowledge is based solely on the role of S1P with an 18-carbon long-chain base length, S1P d18:1. Depending on the
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