830843P

10:0 PA

1,2-didecanoyl-sn-glycero-3-phosphate (sodium salt), powder

• 同義詞: PA(10:0/10:0)
• 經驗公式（希爾表示法）: C₂₃H₄₄O₈PNa
• CAS號碼: 321883-64-1
• 分子量：: 502.55
• 分類程式碼代碼: 51191904
• NACRES: NA.25

屬性

• 化驗: >99% (TLC)
• 形狀: powder
• 包裝: pkg of 1 × 25 mg (830843P-25mg); pkg of 1 × 500 mg (830843P-500mg)
• 製造商／商標名: Avanti Polar Lipids 830843P
• 脂質類型: cardiolipins; phospholipids
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• SMILES 字串: [H][C@@](COP([O-])(O)=O)(OC(CCCCCCCCC)=O)COC(CCCCCCCCC)=O.[Na+]
• InChI: 1S/C23H45O8P.Na/c1-3-5-7-9-11-13-15-17-22(24)29-19-21(20-30-32(26,27)28)31-23(25)18-16-14-12-10-8-6-4-2;/h21H,3-20H2,1-2H3,(H2,26,27,28);/q;+1/p-1/t21-;/m1./s1
• InChI 密鑰: YVHWEENUNNUSBE-ZMBIFBSDSA-M

描述

一般說明

Phosphatidic acid (PA), a minor constituent of biological membranes is a simplest glycerophospholipid. It has glycerol backbone with phosphate present at C-3 position. The C-1 and C-2 positions are esterified with fatty acids.

應用

10:0 PA may be used:

• as a component in the lipid bilayer to study how lipid geometry acts in coat protein I (COPI) vesicle fission
• to study its effects on intracellular Ca²⁺ concentration ([Ca²⁺]i) in C6 rat glioma and L2071 mouse fibroblast cells
• to activate protein kinase C (PKC)
• as a cell-free activator in membrane and cytosolic fractions for nicotinamide adenine dinucleotide phosphate (NADPH) oxidase assay

生化／生理作用

Phosphatidic acid (PA) serves as a lipid second messenger. It can control membrane shape. It is known to participate in cell proliferation, vesicular trafficking, cytoskeletal organization and signal transduction. PA can stimulate negative curvature in lamellar lipid structures. It can block the enzymatic activity of protein phosphatase 1 (PP1).

包裝

30 mL Amber Wide Mouth Bottle with Screw Cap (830843P-500mg)

5 mL Clear Glass Sealed Ampule (830843P-25mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全資訊

• 儲存類別代碼: 11 - Combustible Solids