870320P

N-palmitoyl homocysteine (PHC)

Avanti Research^™ - A Croda Brand 870320P, powder

• 同義詞: N-palmitoyl homocysteine (ammonium salt)
• 經驗公式（希爾表示法）: C₂₀H₄₂N₂O₃S
• CAS號碼: 474942-73-9
• 分子量：: 390.62
• 分類程式碼代碼: 12352211
• NACRES: NA.25

屬性

• 形狀: powder
• 包裝: pkg of 1 × 25 mg (870320P-25mg)
• 製造商／商標名: Avanti Research^™ - A Croda Brand 870320P
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• SMILES 字串: [O-]C(C(NC(CCCCCCCCCCCCCCC)=O)CCS)=O.[NH4+]
• InChI: 1S/C20H39NO3S.H3N/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-19(22)21-18(16-17-25)20(23)24;/h18,25H,2-17H2,1H3,(H,21,22)(H,23,24);1H3
• InChI 密鑰: WUXWCXRWTBPUKZ-UHFFFAOYSA-N

描述

一般說明

N-palmitoyl homocysteine (PHC) is a pH sensitive head group modified lipid.

應用

N-palmitoyl homocysteine (PHC) has been used in the synthesis of micelle-encapsulated temozolomide (TMZ) and targeted rapamycin micelles (TRaM).

生化／生理作用

Liposomes containing pH-sensitive molecules facilitate site-specific drug release in response to the change of pH in the surrounding serum. They deliver drugs or gene fragments into the cytoplasm through the endocytotic pathway. Unlike plain liposomes, pH-sensitive liposomes effectively protect drugs and other encapsulated contents such as enzymes, plasmids, proteins and peptides from being potentially degraded at the lysosomal level. They have a wide range of clinical applications such as a carrier of potent drugs for cancer, pulmonary and infectious diseases, a vaccine adjuvant and a vehicle for contrasting agents during imaging. In addition, pH-sensitive liposomes also facilitate the transport of nucleic acids during gene therapy. DOPE liposomes containing PHC deliver their contents at the early endosome.

包裝

5 mL Amber Glass Screw Cap Vial (870320P-25mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3