830842C

08:0 PA

1,2-dioctanoyl-sn-glycero-3-phosphate (sodium salt), chloroform

• 同義詞: PA(8:0/8:0)
• 經驗公式（希爾表示法）: C₁₉H₃₆O₈PNa
• CAS號碼: 321883-54-9
• 分子量：: 446.45
• 分類程式碼代碼: 51191904
• NACRES: NA.25

屬性

• 化驗: >99% (TLC)
• 形狀: liquid
• 包裝: pkg of 1 × 1 mL (830842C-10mg); pkg of 1 × 2.5 mL (830842C-25mg)
• 製造商／商標名: Avanti Research^™ - A Croda Brand 830842C
• 濃度: 10 mg/mL (830842C-10mg); 10 mg/mL (830842C-25mg)
• 脂質類型: cardiolipins; phospholipids
• 運輸包裝: dry ice
• 儲存溫度: −20°C
• InChI: 1S/C19H37O8P.Na/c1-3-5-7-9-11-13-18(20)25-15-17(16-26-28(22,23)24)27-19(21)14-12-10-8-6-4-2;/h17H,3-16H2,1-2H3,(H2,22,23,24);/q;+1/p-1/t17-;/m1./s1
• InChI 密鑰: ZNDNSOYDPUTHKQ-UNTBIKODSA-M

描述

一般說明

Phosphatidic acid (PA) is a diacyl-glycerophospholipid. Two fatty acids and a phosphate group are attached to a glycerol molecule with the help of covalent bond through ester linkage. PA can be synthesized by the activity of the endogenous enzyme phospholipase D. This prime glycerophospholipid is present in the biomembrane. 08:0 PA (1,2-dioctanoyl-sn-glycero-3-phosphate), a short chain PA is a cell-permeable analog of PA.

應用

08:0 PA has been used to induce differentiation in order to study the effects of phosphatidic acids (PAs) on the inhibition of adipogenic differentiation in 3T3-L1 preadipocytes. It may be used as a mammalian target of rapamycin (mTOR) activator in SGC-996 gall bladder carcinoma cells. It may also be used to study its effects on intracellular Ca²⁺ concentration ([Ca²⁺]i) in C6 rat glioma and L2071 mouse fibroblast cells.

生化／生理作用

Phosphatidic acid (PA) serves as a precursor for phosphatidylcholine or phosphatidylserine. It plays a functional role in influencing the membrane curvature and signaling. C8-PA/08:0 PA can block its association with soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNAREs) to prevent the priming activity on isolated vacuoles. It also has the ability to change the proteolytic cleavage profile of Sec18.

包裝

5 mL Clear Glass Sealed Ampule (830842C-10mg)

5 mL Clear Glass Sealed Ampule (830842C-25mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

安全資訊

• 象形圖: GHS06,GHS08
• 訊號詞: Danger
• 危險聲明: H302,H315,H319,H331,H336,H351,H361d,H372,H412
• 防範說明: P201 - P273 - P301 + P312 + P330 - P302 + P352 - P304 + P340 + P311 - P308 + P313
• 危險分類: Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
• 標靶器官: Central nervous system, Liver,Kidney
• 水污染物質分類（WGK）: WGK 3