推薦產品
化驗
>99% (TLC)
形狀
liquid
包裝
pkg of 1 × 1 mL (810222C-250ug)
pkg of 1 × 1 mg (81022C-1MG)
製造商／商標名
Avanti Research™ - A Croda Brand 810222C
濃度
0.25 mg/mL (810222C-250ug)
運輸包裝
dry ice
儲存溫度
−20°C
一般說明
C6-NBD Glucosyl Ceramide is a fluorescent derivative of biologically active compound, glucosyl ceramide. Glucosyl ceramide belongs to the class of sphingolipids that are synthesized in the cis/medial-Golgi apparatus by the glycosylation of ceramide.
應用
C6-NBD Glucosyl Ceramide may be used as a substrate for glucocerebrosidase (GCase) activity assay in Drosophila melanogaster and mice.
生化／生理作用
Glucosylceramide is the precursor of different glycosphingolipids including gangliosides and sulfatides. Glucosyl ceramide is also known to be responsible for axon growth of neural cells. The accumulation of glucosyl ceramide is associated with an inherited lysosomal storage disorder, Gaucher′s disease.
包裝
5 mL Amber Glass Screw Cap Vial (81022C-1MG)
5 mL Clear Glass Sealed Ampule (810222C-250ug)
法律資訊
Avanti Research is a trademark of Avanti Polar Lipids, LLC
訊號詞
Danger
危險分類
Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3
標靶器官
Central nervous system
水污染物質分類（WGK）
WGK 3
H Zhao et al.
Cellular and molecular life sciences : CMLS, 59(4), 694-707 (2002-05-23)
Gaucher disease is an autosomal recessive trait and the most common lysosomal storage disease. The pathogenesis evolves from the diminished activity of the lysosomal hydrolase, acid beta-glucosidase and the resultant accumulation of glucosylceramide within lysosomes. The pathogenic mechanisms are poorly
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