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重要文件

700147P

Avanti

PhotoClick胆固醇

Hex-5′-ynyl 3β-hydroxy-6-diazirinyl-5α-cholan-24-oate, powder

同義詞:

己-5-炔-1-基4-((3S,5S)-3-羟基-10，13-二甲基-1,2,3,4,5,7,8,9,10,11,12,13,14,15,16,17-十六氢螺[环戊二烯并[α]菲-6,3′-双吖丙啶]-17-基）戊酸酯

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About This Item

經驗公式（希爾表示法）:
C30H46N2O3
CAS號碼:
1485490-47-8
分子量：:
482.70
MDL號碼:
MFCD00870345
分類程式碼代碼:
12352211
NACRES:
NA.25

化驗

>99% (TLC)

形狀

powder

包裝

pkg of 1 × 100 μg (with stopper and crimp cap (700147P-100ug))
pkg of 1 × 250 μg (with stopper and crimp cap (700147P-250ug))

製造商／商標名

Avanti Research™ - A Croda Brand 700147P

脂質類型

click reagents

運輸包裝

dry ice

儲存溫度

−20°C

相關類別

一般說明

PhotoClick胆固醇是一种可点击的光反应性甾醇探针，与定量质谱联用，可直接在活细胞中绘制胆固醇-蛋白质相互作用的全局图。除了可与蛋白质反应的紫外线活化交联双吖丙啶基团外，甾醇还含有炔基，通过点击化学将报告基因和亲和标签结合。
PhotoClick胆固醇是胆固醇的合成类似物，具有光反应性。它包含炔烃基团。

應用

PhotoClick胆固醇已用于：
  • 溶酶体相关膜蛋白1（LAMP1）交联研究
  • 在酵母固醇结合蛋白的结合和竞争分析中作为胆固醇的类似物
  • 作为与溶酶体整合膜蛋白-2（LIMP-2）胞外域的偶联物

生化／生理作用

PhotoClick胆固醇用作跟踪胆固醇结合蛋白的探针。铜催化的叠氮化物-炔烃环加成反应是其探针功能的基础。炔基对点击化学性质至关重要。它与反应伙伴的结合是通过光交联介导的。

包裝

带塞子和压接盖的2 mL琥珀色血清瓶(700147P-100ug)
带塞子和压接盖的2 mL琥珀色血清瓶(700147P-250ug)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

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分析證明 (COA)

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Neha Chauhan et al.
Yeast (Chichester, England), 37(1), 15-25 (2019-11-24)
Ergosterol is a prominent component of the yeast plasma membrane and essential for yeast cell viability. It is synthesized in the endoplasmic reticulum and transported to the plasma membrane by nonvesicular mechanisms requiring carrier proteins. Oxysterol-binding protein homologues and yeast
Jonathan J Hulce et al.
Nature methods, 10(3), 259-264 (2013-02-12)
Cholesterol is an essential structural component of cellular membranes and serves as a precursor for several classes of signaling molecules. Cholesterol exerts its effects and is, itself, regulated in large part by engagement in specific interactions with proteins. The full
Saskia Heybrock et al.
Nature communications, 10(1), 3521-3521 (2019-08-08)
The intracellular transport of cholesterol is subject to tight regulation. The structure of the lysosomal integral membrane protein type 2 (LIMP-2, also known as SCARB2) reveals a large cavity that traverses the molecule and resembles the cavity in SR-B1 that

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