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Key Documents

699851P

Avanti

3A-MPLA

Avanti Research - A Croda Brand 699851P, powder

同義詞:

Monophosphoryl Tri-acyl Lipid A (Synthetic)

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About This Item

經驗公式(希爾表示法):
C54H106N3O17P
CAS號碼:
分子量::
1100.40
分類程式碼代碼:
12352211
NACRES:
NA.25

化驗

>99% (HPLC)

形狀

powder

包裝

pkg of 1 × 1 mg (699851P-1mg)
pkg of 1 × 5 mg (699851P-5mg)

製造商/商標名

Avanti Research - A Croda Brand 699851P

應用

vaccine development

運輸包裝

dry ice

儲存溫度

−20°C

SMILES 字串

O[C@H]([C@@H](CO[C@@H]([C@@H]1NC(C[C@H](OC(CCCCCCCCCCCCC)=O)CCCCCCCCCCC)=O)O[C@H](CO)[C@@H](OP([O-])(O)=O)[C@@H]1O)O[C@H](O)[C@@H]2NC(C[C@H](O)CCCCCCCCCCC)=O)[C@@H]2O.[NH4+]

一般說明

Monophosphoryl lipid A (MPLA) is an analog of the lipid A moiety. It is regarded as a detoxified derivative of the lipopolysaccharide (LPS).

生化/生理作用

Monophosphoryl lipid A (MPLA) is a natural agonist for the toll-like receptor-4 (TLR4). It is useful as an adjuvant in immunization. MPLA is a safe prophylactic agent and has immunotherapeutic applications. It induces tumor necrosis factor and interleukin (IL)-1β, however not as efficient as lipopolysaccharide (LPS). MPLA improves immune response during bacterial sepsis infection.

包裝

2 mL Amber Glass Crimp Cap Vial (699851P-1mg)
2 mL Amber Glass Crimp Cap Vial (699851P-5mg)

其他說明

For R&D use only. Not for drug, household, or other uses.

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

No data available

閃點(°C)

No data available


分析證明 (COA)

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Specific features of human monocytes activation by monophosphoryl lipid A
Chentouh R, et al.
Scientific reports, 8(1), 1-13 (2018)
Monophosphoryl lipid A induces protection against LPS in medullary thick ascending limb through a TLR4-TRIF-PI3K signaling pathway
Watts III BA, et al.
American Journal of Physiology: Renal Physiology, 313(1), F103-F115 (2017)
The TLR4 agonist monophosphoryl lipid a drives broad resistance to infection via dynamic reprogramming of macrophage metabolism
Fensterheim BA, et al.
Journal of Immunology, 200(11), 3777-3789 (2018)

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