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重要文件

141101C

Avanti

Brain Extract Polar

Avanti Research - A Croda Brand

同義詞:

Brain Polar Lipid Extract (Porcine)

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About This Item

CAS號碼:
MDL號碼:
分類程式碼代碼:
12352211
NACRES:
NA.25

形狀

chloroform solution

包裝

pkg of 1 × 4 mL (141101C-100mg)
pkg of 5 × 4 mL (141101C-500mg)

製造商/商標名

Avanti Research - A Croda Brand

濃度

25 mg/mL (141101C-100mg)
25 mg/mL (141101C-500mg)

脂質類型

lipid extracts

運輸包裝

dry ice

儲存溫度

−20°C

一般說明

Brain Extract Polar comprises phosphatidylethanolamine as major lipid component. It also contains phosphatidylserine and phosphatidylcholine. The minor components include the phosphatidic acid and phosphatidylinositol.
Brain Polar Lipid Extract is derived from the total lipid extract by precipitation with acetone followed by extraction of the acetone insoluble material with diethyl ether.

應用

Brain Extract Polar has been used as an artificial membrane solution component for permeability studies. It may be used for coating donor plate during parallel artificial membrane permeability assay (PAMPA) to study blood-brain barrier penetration. It may be used in liposome preparation for dynamin self-assembly assay.

生化/生理作用

Brain lipid, especially the polar fraction plays a key role in the inhibition of prion seeded amyloid formation. Lipid extracts from the mammalian tissues like brain, kidney and liver are used in generating model membranes for mimicking real membranes.

包裝

5 mL Clear Glass Sealed Ampule (141101C-100mg)
5 mL Clear Glass Sealed Ampule (141101C-500mg)

法律資訊

Avanti Research is a trademark of Avanti Polar Lipids, LLC

象形圖

Skull and crossbonesHealth hazard

訊號詞

Danger

危險分類

Acute Tox. 3 Inhalation - Acute Tox. 4 Oral - Aquatic Chronic 3 - Carc. 2 - Eye Irrit. 2 - Repr. 2 - Skin Irrit. 2 - STOT RE 1 - STOT SE 3

標靶器官

Central nervous system, Liver,Kidney

儲存類別代碼

6.1D - Non-combustible acute toxic Cat.3 / toxic hazardous materials or hazardous materials causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

does not flash

閃點(°C)

does not flash


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分析證明 (COA)

Lot/Batch Number

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Chameleon-like behavior of indolylpiperidines in complex with cholinesterases targets: Potent butyrylcholinesterase inhibitors
Chierrito TPC, et al.
European Journal of Medicinal Chemistry, 145(10), 431-444 (2018)
Prediction of blood-brain barrier permeation of alpha-adrenergic and imidazoline receptor ligands using PAMPA technique and quantitative-structure permeability relationship analysis
Vucicevic J, et al.
European Journal of Pharmaceutical Sciences, 68(10), 94-105 (2015)
Kalirin12 interacts with dynamin
Xin X, et al.
BMC Neuroscience, 10(1), 61-61 (2009)
Estefanía de Munck et al.
PloS one, 11(9), e0162723-e0162723 (2016-09-16)
Amyotrophic lateral sclerosis (ALS) is a progressive motor neuron degenerative disease that has no effective treatment up to date. Drug discovery tasks have been hampered due to the lack of knowledge in its molecular etiology together with the limited animal
Endogenous brain lipids inhibit prion amyloid formation in vitro
Hoover CE, et al.
Journal of Virology, 91(9), e02162-e02116 (2017)

Global Trade Item Number

庫存單位GTIN
141101C-100MG4061838169037
141101C-500MG4061838169044

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