QBD10273

Fmoc-N-amido-dPEG^®₈-acid

>95% (HPLC)

• 同義詞: Fmoc-N-amido-PEG₈-COOH, Fmoc-N-amido-PEG₈-acid, Fmoc-NH-PEG₈-acid, Fmoc-PEG-acid
• 經驗公式（希爾表示法）: C₃₄H₄₉NO₁₂
• 分子量：: 663.75
• MDL號碼: MFCD11041143
• 分類程式碼代碼: 12352106
• NACRES: NA.22

屬性

• 化驗: >95% (HPLC)
• 形狀: solid or viscous liquid
• 反應適用性: reaction type: Pegylations
• 聚合物結構: shape: linear; functionality: heterobifunctional
• 運輸包裝: ambient
• 儲存溫度: −20°C
• SMILES 字串: N(CCOCCOCCOCCOCCOCCOCCOCCOCCC(=O)O)C(=O)OCC1c2c(cccc2)c3c1cccc3
• InChI 密鑰: VYXGUCLTEWCVRY-UHFFFAOYSA-N

描述

特點和優勢

Fmoc-N-amido-dPEG₈-acid is a monodisperse PEG product that is useful for peptide synthesis. The 28-atom dPEG spacer allows the introduction of a medium-length, hydrophilic spacer onto either end of a peptide chain or between two peptide chains. The flexible dPEG spacer conjugates to peptides using conventional peptide synthesis chemistry. Peptide PEGylation imparts water solubility to hydrophobic peptide chains. Also, PEGylated peptides have expanded hydrodynamic volumes, which can reduce or eliminate renal clearance, and are protected from proteolysis. The combination of decreased renal clearance and protection from proteolysis contributes to longer in vivo circulation times for PEGylated (as compared to non-PEGylated) peptides. Additionally, PEGylation diminishes a peptide′s antigenicity. This product is part of the Fmoc-N-amido-dPEG_n-acid (n=2, 3, 4, 5, 6, 8, 12, 24, 36) product series.

法律資訊

Products Protected under U.S. Patent #s 7,888,536 & 8,637,711 and European Patent #s 1,594,440 & 2,750,681

dPEG is a registered trademark of Quanta BioDesign

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable