QBD10181

dPEG^®₄-SATA (S-acetyl-dPEG^®₄-NHS ester)

• 同義詞: 2,5-Dioxo-1-pyrrolidinyl 17-oxo-4,7,10,13-tetraoxa-16-thiaoctadecanoate, Acetyl-S-dPEG4-NHS ester, N-Succinimidyl S-acetyl(thiotetraethylene glycol), Polyethylene glycol
• 經驗公式（希爾表示法）: C₁₇H₂₇NO₉S
• CAS號碼: 937025-17-7
• 分子量：: 421.46
• MDL號碼: MFCD11041102
• 分類程式碼代碼: 12352108
• PubChem物質ID: 329823884
• NACRES: NA.22

屬性

• 化驗: >90%
• 形狀: solid or viscous liquid
• 反應適用性: reagent type: chemical modification reagent; reagent type: cross-linking reagent; reactivity: amine reactive
• 聚合物結構: shape: linear; functionality: monofunctional
• 運輸包裝: ambient
• 儲存溫度: −20°C
• SMILES 字串: CC(SCCOCCOCCOCCOCCC(ON1C(CCC1=O)=O)=O)=O

描述

特點和優勢

dPEG^®₄-SATA (S-acetyl-dPEG^®₄-NHS ester) contains an acetyl-protected thiol on one end of a single molecular weight dPEG^® linker and an amine-reactive N-hydroxysuccinimide (NHS) ester on the other end. One or more free primary amines on the target molecule can be reacted with dPEG^®₄-SATA to install a protected thiol connected to the molecule via the dPEG^® linker. Three different linker lengths provide precise distance control between the target molecule and the acetyl-protected thiol group. The dPEG^® linker imparts water solubility and reduced immunogenicity to the target molecule. Compared to reagents containing only hydrocarbon spacers, dPEG^®-containing reagents also reduce aggregation and precipitation of crosslinked proteins. The acetyl group is easily removed by mild chemical deprotection with hydroxylamine hydrochloride, exposing the free thiol, which can then be used to form a disulfide or thiol ether bond to another molecule. Although commonly used with proteins, these reagents are also suitable for any small molecules or peptides with suitable functionalities.

法律資訊

Products Protected under U.S. Patents # 7,888,536 B2

dPEG is a registered trademark of Quanta BioDesign

安全資訊

• 儲存類別代碼: 11 - Combustible Solids
• 水污染物質分類（WGK）: WGK 3
• 閃點（°F）: Not applicable
• 閃點（°C）: Not applicable