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Key Documents

B10102

Sigma-Aldrich

苯并[e]芘

98%

同義詞:

1,2-苯并芘, 4,5-苯并芘

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About This Item

經驗公式(希爾表示法):
C20H12
CAS號碼:
分子量::
252.31
Beilstein:
1911334
EC號碼:
MDL號碼:
分類程式碼代碼:
12352103
PubChem物質ID:
NACRES:
NA.23

化驗

98%

形狀

crystals

mp

177-180 °C (lit.)

SMILES 字串

c1ccc2c(c1)c3cccc4ccc5cccc2c5c34

InChI

1S/C20H12/c1-2-8-16-15(7-1)17-9-3-5-13-11-12-14-6-4-10-18(16)20(14)19(13)17/h1-12H

InChI 密鑰

TXVHTIQJNYSSKO-UHFFFAOYSA-N

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一般說明

这种多环芳烃可溶于丙酮。它是一种非致癌的苯并芘异构体。 研究显示,它在体内和体外暴露后无免疫抑制活性。在自然界中,它被秀丽隐杆线虫菌株代谢为3-苯并[e]芘硫酸盐、1-羟基-3-苯并[e]芘基硫酸盐和苯并[e]芘3-O-β-吡喃葡萄糖苷。

應用

用于研究苯并[e]芘对DNP-Ficoll和绵羊红细胞的抗体反应的免疫抑制活性 以及从水样中提取有机化合物的“分散液-液微萃取”技术。

象形圖

Health hazardEnvironment

訊號詞

Danger

危險聲明

危險分類

Aquatic Acute 1 - Aquatic Chronic 1 - Carc. 1B

儲存類別代碼

6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable

個人防護裝備

Eyeshields, Gloves, type P3 (EN 143) respirator cartridges


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K L White et al.
Cancer research, 44(8), 3388-3393 (1984-08-01)
The role of metabolic activation of benzo(a)pyrene B(a)P in mediating its suppression of humoral immune responsiveness of the female C57BL/6 X C3H F1 (hereafter called B6C3F1) mouse was addressed in these studies. The model was the in vitro antibody response
Mohammad Rezaee et al.
Journal of chromatography. A, 1116(1-2), 1-9 (2006-04-01)
A new microextraction technique termed dispersive liquid-liquid microextraction (DLLME) was developed. DLLME is a very simple and rapid method for extraction and preconcentration of organic compounds from water samples. In this method, the appropriate mixture of extraction solvent (8.0 microL
D W Rosenberg et al.
Archives of biochemistry and biophysics, 300(1), 186-192 (1993-01-01)
The consequences of altered cytochrome P450-dependent monooxygenase activities in colonic tissue are unknown. As an initial step toward elucidating underlying mechanisms that regulate cytochrome P450 levels in colonic epithelium, we have characterized CYP1A1(3) induction in cultured human colonic cells (Caco-2).
S Faiderbe et al.
Cancer research, 52(10), 2862-2865 (1992-05-15)
High levels of anti-phosphatidylinositol (PtdIns) autoantibodies (autoAb) have been previously described in sera of cancer patients and in plasma of dimethylbenzanthracene-treated female Sprague-Dawley rats. The presence of anti-PtdIns autoAb was tested in a model of highly malignant sarcomas induced by
K Sterling et al.
Toxicology and applied pharmacology, 128(1), 18-24 (1994-09-01)
Hepa 1c1c7 (WT), TAOc1BPrc1 (CI), and BPrc1 (CII) mouse hepatoma cells were exposed to benzo[e]pyrene (B[e]P) or benzo[a]pyrene (B[a]P). B[e]P induced activity of a rat CYP1A1 reporter gene construct (-3015 to +2545 bp) by 1.8- to 2-fold and 5-fold in

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