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Merck
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Key Documents

ALD00610

Sigma-Aldrich

2-(4-Chloro-6-methoxy-1,3,5-triazin-2-yl)benzonitrile

≥95%

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About This Item

經驗公式(希爾表示法):
C11H7ClN4O
CAS號碼:
分子量::
246.65
分類程式碼代碼:
12352101
NACRES:
NA.22

化驗

≥95%

形狀

powder

反應適用性

reaction type: C-C Bond Formation
reagent type: catalyst
reaction type: C-H Activation

mp

156-159 °C

儲存溫度

−20°C

應用

2-(4-Chloro-6-methoxy-1,3,5-triazin-2-yl)benzonitrile is a bifunctional C-H activation template developed in the Yu lab for the conversion of phenols to 1,3-disubstituted arenes. The template is used for a one-pot Pd-catalyzed meta-selective C-H olefination of phenols followed by a nickel-catalyzed ipso-C-O activation and arylation.

相關產品

儲存類別代碼

11 - Combustible Solids

水污染物質分類(WGK)

WGK 3

閃點(°F)

Not applicable

閃點(°C)

Not applicable


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Jiancong Xu et al.
Journal of the American Chemical Society, 141(5), 1903-1907 (2019-01-23)
The use of a template as a linchpin motif in directed remote C-H functionalization is a versatile yet relatively underexplored strategy. We have developed a template-directed approach to realizing one-pot sequential palladium-catalyzed meta-selective C-H olefination of phenols, and nickel-catalyzed ipso-C-O

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